Lithium transport across biological membranes.
Research output: Contribution to journal › Journal article › Research › peer-review
Li+ is actively transported out of cells, and across different epithelia of both mammalian and amphibian origin. Due to the low affinity of the Na+/K(+)-ATPase for Li+, the transport is most likely energized by exchange and/or cotransport processes. The detailed mechanism by which Li+ is reabsorbed across the proximal tubule is not known, although it seems reasonable to assume that at least a part is by secondary active transcellular transport. The evidence further suggest that aldosterone and maybe vasopressin, through their effects on the Na+ channels in the late distal tubule and the collecting duct may be of significance in inducing distal Li+ reabsorption, as seen during severe sodium restriction in rats and dogs. Clearly more studies are needed to finally resolve these issues.
Original language | English |
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Book series | Kidney International. Supplement |
Volume | 28 |
Pages (from-to) | S4-9 |
ISSN | 0098-6577 |
Publication status | Published - 1990 |
Bibliographical note
Keywords: Absorption; Animals; Biological Transport; Epithelium; Erythrocytes; Humans; Intestines; Kidney Tubules; Lithium; Permeability; Skin; Sodium
ID: 8439994