Lifestyle intervention leading to moderate weight loss normalizes postprandial triacylglycerolemia despite persisting obesity
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Lifestyle intervention leading to moderate weight loss normalizes postprandial triacylglycerolemia despite persisting obesity. / Maraki, Maria I; Aggelopoulou, Niki; Christodoulou, Nektarios; Anastasiou, Costas A; Toutouza, Marina; Panagiotakos, Demosthenes B; Kavouras, Stavros A; Magkos, Faidon; Sidossis, Labros S.
In: Obesity, Vol. 19, No. 5, 2011, p. 968-976.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lifestyle intervention leading to moderate weight loss normalizes postprandial triacylglycerolemia despite persisting obesity
AU - Maraki, Maria I
AU - Aggelopoulou, Niki
AU - Christodoulou, Nektarios
AU - Anastasiou, Costas A
AU - Toutouza, Marina
AU - Panagiotakos, Demosthenes B
AU - Kavouras, Stavros A
AU - Magkos, Faidon
AU - Sidossis, Labros S
N1 - (Ekstern)
PY - 2011
Y1 - 2011
N2 - Obesity is associated with impaired postprandial triacylglycerolemia, an independent risk factor for cardiovascular disease. Given that obesity is hard to treat, efforts should focus on treating its comorbidities. We aimed to investigate whether moderate weight loss normalizes postprandial triacylglycerol (TAG) concentrations, in the absence of the acute effects of negative energy balance. For this purpose, postprandial lipemia was investigated in eight obese but otherwise healthy, sedentary men (age: 41.3 ± 4.1 years, BMI: 36.5 ± 1.6 kg·m(-2)), once before and again after a 10% weight loss followed by ≥4 weeks of weight maintenance, and was compared with that of eight age-matched healthy lean men (BMI: 24.7 ± 0.6 kg·m(-2)). Dietary intervention consisted of reduced carbohydrate and saturated fat intake and increased monounsaturated fat intake. Obese volunteers were advised to increase physical activity using pedometers to record daily activity. Postprandial triacylglycerolemia after weight loss was reduced by 27-46% (P < 0.05), and became similar to that of lean men despite persisting obesity (BMI after weight loss: 32.9 ± 1.5 kg·m(-2)). Reduction in postprandial TAG responses was inversely correlated with the decrease in postprandial insulin sensitivity index (ISI) after weight loss (r = -0.714, P = 0.047). We conclude that moderate weight loss induced by a low-carbohydrate and saturated fat diet and a slight increase in daily physical activity normalizes postprandial triacylglycerolemia in obese men, independently of acute diet-induced negative energy balance, and possibly through enhancement of insulin action.
AB - Obesity is associated with impaired postprandial triacylglycerolemia, an independent risk factor for cardiovascular disease. Given that obesity is hard to treat, efforts should focus on treating its comorbidities. We aimed to investigate whether moderate weight loss normalizes postprandial triacylglycerol (TAG) concentrations, in the absence of the acute effects of negative energy balance. For this purpose, postprandial lipemia was investigated in eight obese but otherwise healthy, sedentary men (age: 41.3 ± 4.1 years, BMI: 36.5 ± 1.6 kg·m(-2)), once before and again after a 10% weight loss followed by ≥4 weeks of weight maintenance, and was compared with that of eight age-matched healthy lean men (BMI: 24.7 ± 0.6 kg·m(-2)). Dietary intervention consisted of reduced carbohydrate and saturated fat intake and increased monounsaturated fat intake. Obese volunteers were advised to increase physical activity using pedometers to record daily activity. Postprandial triacylglycerolemia after weight loss was reduced by 27-46% (P < 0.05), and became similar to that of lean men despite persisting obesity (BMI after weight loss: 32.9 ± 1.5 kg·m(-2)). Reduction in postprandial TAG responses was inversely correlated with the decrease in postprandial insulin sensitivity index (ISI) after weight loss (r = -0.714, P = 0.047). We conclude that moderate weight loss induced by a low-carbohydrate and saturated fat diet and a slight increase in daily physical activity normalizes postprandial triacylglycerolemia in obese men, independently of acute diet-induced negative energy balance, and possibly through enhancement of insulin action.
KW - Adult
KW - Body Mass Index
KW - Caloric Restriction
KW - Cardiovascular Diseases/epidemiology
KW - Diet, Reducing
KW - Humans
KW - Hypertriglyceridemia/blood
KW - Insulin Resistance
KW - Male
KW - Obesity/blood
KW - Postprandial Period
KW - Risk Reduction Behavior
KW - Treatment Outcome
KW - Triglycerides/blood
KW - Weight Loss
U2 - 10.1038/oby.2010.218
DO - 10.1038/oby.2010.218
M3 - Journal article
C2 - 20885389
VL - 19
SP - 968
EP - 976
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 5
ER -
ID: 290522093