Interstitial K+ in human skeletal muscle during and after dynamic graded exercise determined by microdialysis
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Interstitial K+ in human skeletal muscle during and after dynamic graded exercise determined by microdialysis. / Juel, Carsten; Pilegaard, Henriette; Nielsen, Jens Jung; Bangsbo, Jens.
In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 278, No. 2, 2000, p. R400-R406.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Interstitial K+ in human skeletal muscle during and after dynamic graded exercise determined by microdialysis
AU - Juel, Carsten
AU - Pilegaard, Henriette
AU - Nielsen, Jens Jung
AU - Bangsbo, Jens
PY - 2000
Y1 - 2000
N2 - Interstitial K+ concentrations were measured during one-legged knee- extensor exercise by use of microdialysis with probes inserted in the vastus lateralis muscle of the subjects. K+ in the dialysate was measured either by flame photometry or a K+-sensitive electrode placed in the perfusion outlet. The correction for fractional K+ recovery was based on the assumption of identical fractional thallium loss. The interstitial K+ was 4.19 ± 0.09 mM at rest and increased to 6.17 ± 0.19, 7.48 ± 1.18, and 9.04 ± 0.74 mM at 10, 30, and 50 W exercise, respectively. The individual probes demonstrated large variations in interstitial K+, and values >10 mM were obtained. The observed interstitial K+, was markedly higher than previously found for venous K+, concentrations at similar work intensities. The present data support a potential role for interstitial K+, in regulation of blood flow and development of fatigue.
AB - Interstitial K+ concentrations were measured during one-legged knee- extensor exercise by use of microdialysis with probes inserted in the vastus lateralis muscle of the subjects. K+ in the dialysate was measured either by flame photometry or a K+-sensitive electrode placed in the perfusion outlet. The correction for fractional K+ recovery was based on the assumption of identical fractional thallium loss. The interstitial K+ was 4.19 ± 0.09 mM at rest and increased to 6.17 ± 0.19, 7.48 ± 1.18, and 9.04 ± 0.74 mM at 10, 30, and 50 W exercise, respectively. The individual probes demonstrated large variations in interstitial K+, and values >10 mM were obtained. The observed interstitial K+, was markedly higher than previously found for venous K+, concentrations at similar work intensities. The present data support a potential role for interstitial K+, in regulation of blood flow and development of fatigue.
KW - Fatigue
KW - Regulation of blood flow
UR - http://www.scopus.com/inward/record.url?scp=0034012317&partnerID=8YFLogxK
M3 - Journal article
C2 - 10666141
AN - SCOPUS:0034012317
VL - 278
SP - R400-R406
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 2
ER -
ID: 210151349