Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation

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Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation. / Frederiksen, Tanja Charlotte; Christiansen, Morten Krogh; Benjamin, Emelia J.; Overvad, Kim; Olsen, Anja; Andersen, Mette K.; Hansen, Torben; Grarup, Niels; Jensen, Henrik Kjaerulf; Dahm, Christina C.

In: Heart, Vol. 110, 2024, p. :644–649.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Frederiksen, TC, Christiansen, MK, Benjamin, EJ, Overvad, K, Olsen, A, Andersen, MK, Hansen, T, Grarup, N, Jensen, HK & Dahm, CC 2024, 'Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation', Heart, vol. 110, pp. :644–649. https://doi.org/10.1136/heartjnl-2023-323333

APA

Frederiksen, T. C., Christiansen, M. K., Benjamin, E. J., Overvad, K., Olsen, A., Andersen, M. K., Hansen, T., Grarup, N., Jensen, H. K., & Dahm, C. C. (2024). Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation. Heart, 110, :644–649. https://doi.org/10.1136/heartjnl-2023-323333

Vancouver

Frederiksen TC, Christiansen MK, Benjamin EJ, Overvad K, Olsen A, Andersen MK et al. Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation. Heart. 2024;110::644–649. https://doi.org/10.1136/heartjnl-2023-323333

Author

Frederiksen, Tanja Charlotte ; Christiansen, Morten Krogh ; Benjamin, Emelia J. ; Overvad, Kim ; Olsen, Anja ; Andersen, Mette K. ; Hansen, Torben ; Grarup, Niels ; Jensen, Henrik Kjaerulf ; Dahm, Christina C. / Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation. In: Heart. 2024 ; Vol. 110. pp. :644–649.

Bibtex

@article{e99675b242bb48a0bfe137a4564682cb,

title = "Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation",

abstract = "Background: The relationship between combined genetic predisposition and lifestyle and the risk of incident atrial fibrillation (AF) is unclear. Therefore, we aimed to assess a possible interaction between lifestyle and genetics on AF risk. Methods: We included AF cases and a randomly drawn subcohort of 4040 participants from the Danish Diet, Cancer and Health cohort. Lifestyle risk factors were assessed, a score was calculated, and participants were categorised as having a poor, intermediate, or ideal lifestyle. We calculated a genetic risk score comprising 142 variants, and categorised participants into low (quintile 1), intermediate (quintiles 2-4) or high (quintile 5) genetic risk of AF. Results: 3094 AF cases occurred during a median follow-up of 12.9 years. Regardless of genetic risk, incidence rates per 1000 person-years were gradually higher with worse lifestyle. For participants with high genetic risk, the incidence rates of AF per 1000 person-years were 5.0 (95% CI 3.4 to 7.3) among individuals with ideal lifestyle, 6.6 (95% CI 5.4 to 8.1) among those with intermediate lifestyle and 10.4 (95% CI 9.2 to 11.8) among participants with poor lifestyle. On an additive scale, there was a positive statistically significant interaction between genetic risk and lifestyle (relative excess risk due to interaction=0.86, 95% CI 0.68 to 1.03, p<0.001). Conclusions: The rates of AF increased gradually with worse lifestyle within each category of genetic risk. We found a positive interaction on an additive scale between genetic risk and lifestyle, suggesting that risk factor modification is especially important in individuals with a high genetic risk of AF.",

keywords = "Atrial Fibrillation, Epidemiology, Genetics",

author = "Frederiksen, {Tanja Charlotte} and Christiansen, {Morten Krogh} and Benjamin, {Emelia J.} and Kim Overvad and Anja Olsen and Andersen, {Mette K.} and Torben Hansen and Niels Grarup and Jensen, {Henrik Kjaerulf} and Dahm, {Christina C.}",

note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2024",

doi = "10.1136/heartjnl-2023-323333",

language = "English",

volume = "110",

pages = ":644–649",

journal = "Heart",

issn = "1355-6037",

publisher = "B M J Group",

}

RIS

TY - JOUR

T1 - Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation

AU - Frederiksen, Tanja Charlotte

AU - Christiansen, Morten Krogh

AU - Benjamin, Emelia J.

AU - Overvad, Kim

AU - Olsen, Anja

AU - Andersen, Mette K.

AU - Hansen, Torben

AU - Grarup, Niels

AU - Jensen, Henrik Kjaerulf

AU - Dahm, Christina C.

PY - 2024

Y1 - 2024

N2 - Background: The relationship between combined genetic predisposition and lifestyle and the risk of incident atrial fibrillation (AF) is unclear. Therefore, we aimed to assess a possible interaction between lifestyle and genetics on AF risk. Methods: We included AF cases and a randomly drawn subcohort of 4040 participants from the Danish Diet, Cancer and Health cohort. Lifestyle risk factors were assessed, a score was calculated, and participants were categorised as having a poor, intermediate, or ideal lifestyle. We calculated a genetic risk score comprising 142 variants, and categorised participants into low (quintile 1), intermediate (quintiles 2-4) or high (quintile 5) genetic risk of AF. Results: 3094 AF cases occurred during a median follow-up of 12.9 years. Regardless of genetic risk, incidence rates per 1000 person-years were gradually higher with worse lifestyle. For participants with high genetic risk, the incidence rates of AF per 1000 person-years were 5.0 (95% CI 3.4 to 7.3) among individuals with ideal lifestyle, 6.6 (95% CI 5.4 to 8.1) among those with intermediate lifestyle and 10.4 (95% CI 9.2 to 11.8) among participants with poor lifestyle. On an additive scale, there was a positive statistically significant interaction between genetic risk and lifestyle (relative excess risk due to interaction=0.86, 95% CI 0.68 to 1.03, p<0.001). Conclusions: The rates of AF increased gradually with worse lifestyle within each category of genetic risk. We found a positive interaction on an additive scale between genetic risk and lifestyle, suggesting that risk factor modification is especially important in individuals with a high genetic risk of AF.

AB - Background: The relationship between combined genetic predisposition and lifestyle and the risk of incident atrial fibrillation (AF) is unclear. Therefore, we aimed to assess a possible interaction between lifestyle and genetics on AF risk. Methods: We included AF cases and a randomly drawn subcohort of 4040 participants from the Danish Diet, Cancer and Health cohort. Lifestyle risk factors were assessed, a score was calculated, and participants were categorised as having a poor, intermediate, or ideal lifestyle. We calculated a genetic risk score comprising 142 variants, and categorised participants into low (quintile 1), intermediate (quintiles 2-4) or high (quintile 5) genetic risk of AF. Results: 3094 AF cases occurred during a median follow-up of 12.9 years. Regardless of genetic risk, incidence rates per 1000 person-years were gradually higher with worse lifestyle. For participants with high genetic risk, the incidence rates of AF per 1000 person-years were 5.0 (95% CI 3.4 to 7.3) among individuals with ideal lifestyle, 6.6 (95% CI 5.4 to 8.1) among those with intermediate lifestyle and 10.4 (95% CI 9.2 to 11.8) among participants with poor lifestyle. On an additive scale, there was a positive statistically significant interaction between genetic risk and lifestyle (relative excess risk due to interaction=0.86, 95% CI 0.68 to 1.03, p<0.001). Conclusions: The rates of AF increased gradually with worse lifestyle within each category of genetic risk. We found a positive interaction on an additive scale between genetic risk and lifestyle, suggesting that risk factor modification is especially important in individuals with a high genetic risk of AF.

KW - Atrial Fibrillation

KW - Epidemiology

KW - Genetics

U2 - 10.1136/heartjnl-2023-323333

DO - 10.1136/heartjnl-2023-323333

M3 - Journal article

C2 - 38016806

AN - SCOPUS:85178639616

VL - 110

SP - :644–649

JO - Heart

JF - Heart

SN - 1355-6037

ER -

ID: 378329140