Insulin-like Growth Factor Receptor 1 mRNA Expression as a Prognostic Marker in Advanced Non-small Cell Lung Cancer
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BACKGROUND: The insulin-like growth factor 1 receptor (IGF1R) has yet to be established as a biomarker in non-small cell lung cancer (NSCLC) but could prove useful in customized chemotherapy. We explored its prognostic value using both quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC).
MATERIALS AND METHODS: Analyses of IGF1R were performed on patients with advanced NSCLC, included in a randomized chemotherapy trial, having large, representative tissue samples. IGF1R mRNA and protein expression were correlated to clinical end-points.
RESULTS: Surgical tissue samples were available from 33 patients deemed inoperable. IGF1R status varied according to histopathology. Patients with tumors positive for IGF1R mRNA expression had a shorter progression-free and overall survival when compared to the negative sub-group (6.1 vs. 7.4 months, p=0.039 and 10.9 vs. 14.3 months, p=0.038, respectively). IGF1R protein expression showed a similar, although non-significant tendency.
CONCLUSION: IGF1R mRNA expression may be a prognostic biomarker in advanced NSCLC and should be investigated in a larger population.
Original language | English |
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Journal | Anticancer Research |
Volume | 34 |
Issue number | 6 |
Pages (from-to) | 2991-2996 |
Number of pages | 6 |
ISSN | 0250-7005 |
Publication status | Published - Jun 2014 |
- Adenocarcinoma, Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Large Cell, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Cohort Studies, Female, Follow-Up Studies, Humans, Immunoenzyme Techniques, Lung Neoplasms, Male, Middle Aged, Neoplasm Staging, Prognosis, RNA, Messenger, Real-Time Polymerase Chain Reaction, Receptor, IGF Type 1, Reverse Transcriptase Polymerase Chain Reaction, Survival Rate, Tumor Markers, Biological, Young Adult
Research areas
ID: 138218850