Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE)
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Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). / Raiten, Daniel J; Sakr Ashour, Fayrouz A; Ross, A Catharine; Meydani, Simin N; Dawson, Harry D; Stephensen, Charles B; Brabin, Bernard J; Suchdev, Parminder S; van Ommen, Ben; INSPIRE Consultative Group ; Friis, Henrik.
In: Journal of Nutrition, Vol. 145, No. 5, 2015, p. 1039S-1108S.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE)
AU - Raiten, Daniel J
AU - Sakr Ashour, Fayrouz A
AU - Ross, A Catharine
AU - Meydani, Simin N
AU - Dawson, Harry D
AU - Stephensen, Charles B
AU - Brabin, Bernard J
AU - Suchdev, Parminder S
AU - van Ommen, Ben
AU - INSPIRE Consultative Group
AU - Friis, Henrik
N1 - CURIS 2015 NEXS 267
PY - 2015
Y1 - 2015
N2 - An increasing recognition has emerged of the complexities of the global health agenda—specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and the development and function of the immune and inflammatory response and 2) the specific impact of the inflammatory response on the selection, use, and interpretation of nutrient biomarkers. The goal of the Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE) is to provide guidance for those users represented by the global food and nutrition enterprise. These include researchers (bench and clinical), clinicians providing care/treatment, those developing and evaluating programs/interventions at scale, and those responsible for generating evidence-based policy. The INSPIRE process included convening 5 thematic working groups (WGs) charged with developing summary reports around the following issues: 1) basic overview of the interactions between nutrition, immune function, and the inflammatory response; 2) examination of the evidence regarding the impact of nutrition on immune function and inflammation; 3) evaluation of the impact of inflammation and clinical conditions (acute and chronic) on nutrition; 4) examination of existing and potential new approaches to account for the impact of inflammation on biomarker interpretation and use; and 5) the presentation of new approaches to the study of these relations. Each WG was tasked with synthesizing a summary of the evidence for each of these topics and delineating the remaining gaps in our knowledge. This review consists of a summary of the INSPIRE workshop and the WG deliberations.
AB - An increasing recognition has emerged of the complexities of the global health agenda—specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and the development and function of the immune and inflammatory response and 2) the specific impact of the inflammatory response on the selection, use, and interpretation of nutrient biomarkers. The goal of the Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE) is to provide guidance for those users represented by the global food and nutrition enterprise. These include researchers (bench and clinical), clinicians providing care/treatment, those developing and evaluating programs/interventions at scale, and those responsible for generating evidence-based policy. The INSPIRE process included convening 5 thematic working groups (WGs) charged with developing summary reports around the following issues: 1) basic overview of the interactions between nutrition, immune function, and the inflammatory response; 2) examination of the evidence regarding the impact of nutrition on immune function and inflammation; 3) evaluation of the impact of inflammation and clinical conditions (acute and chronic) on nutrition; 4) examination of existing and potential new approaches to account for the impact of inflammation on biomarker interpretation and use; and 5) the presentation of new approaches to the study of these relations. Each WG was tasked with synthesizing a summary of the evidence for each of these topics and delineating the remaining gaps in our knowledge. This review consists of a summary of the INSPIRE workshop and the WG deliberations.
KW - Animals
KW - Biological Markers
KW - Biomedical Research
KW - Congresses as Topic
KW - Diet
KW - Evidence-Based Medicine
KW - Food Technology
KW - Global Health
KW - Humans
KW - Immunologic Techniques
KW - Inflammation Mediators
KW - Nutrition Policy
KW - Nutritional Sciences
KW - Terminology as Topic
U2 - 10.3945/jn.114.194571
DO - 10.3945/jn.114.194571
M3 - Journal article
C2 - 25833893
VL - 145
SP - 1039S-1108S
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 5
ER -
ID: 142063276