Infant BMI peak, breastfeeding, and body composition at age 3 y
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Infant BMI peak, breastfeeding, and body composition at age 3 y. / Jensen, Signe Marie; Ritz, Christian; Ejlerskov, Katrine Tschentscher; Mølgaard, Christian; Michaelsen, Kim F.
In: American Journal of Clinical Nutrition, Vol. 101, No. 2, 2015, p. 319-325.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Infant BMI peak, breastfeeding, and body composition at age 3 y
AU - Jensen, Signe Marie
AU - Ritz, Christian
AU - Ejlerskov, Katrine Tschentscher
AU - Mølgaard, Christian
AU - Michaelsen, Kim F.
N1 - CURIS 2015 NEXS 064
PY - 2015
Y1 - 2015
N2 - BACKGROUND: With the increasing focus on obesity, growth patterns in infancy and early childhood have gained much attention. Although the adiposity rebound has been in focus because of a shown association with adult obesity, not much has been published about the infant peak in body mass index (BMI).OBJECTIVE: This study links age and BMI at infant peak to duration of breastfeeding and body composition at 3 y of age.DESIGN: Frequent weight and height measurements for 311 Danish children in the SKOT (Complementary and Young Child Feeding - Impact on Short and Long Term Development and Health; in Danish) cohort were used to estimate BMI growth curves for the age span from 14 d to 19 mo by using a nonlinear mixed-effects model. BMI growth velocity before peak and age and BMI at peak were derived from the subject-specific models. Information about pregnancy and breastfeeding was assessed from background questionnaires. Assessment of body composition at age 3 y was made based on bioelectrical impedance, weight, and height.RESULTS: A longer duration of exclusive breastfeeding was associated with an earlier peak in infant BMI (P = 0.0003) and a lower prepeak velocity (P < 0.0001). BMI level at peak and prepeak velocity was positively associated with fat and fat-free mass at age 3 y (all P < 0.0001), whereas a later age at peak was associated with a lower fat mass, fat mass index, and fat-free mass index at age 3 y (all P < 0.001).CONCLUSIONS: BMI peak characteristics are strongly associated with both duration of exclusive breastfeeding and body composition at 3 y of age. Thus, a better knowledge of characteristics and determinants of the early BMI peak is likely to improve our understanding of early development of obesity.
AB - BACKGROUND: With the increasing focus on obesity, growth patterns in infancy and early childhood have gained much attention. Although the adiposity rebound has been in focus because of a shown association with adult obesity, not much has been published about the infant peak in body mass index (BMI).OBJECTIVE: This study links age and BMI at infant peak to duration of breastfeeding and body composition at 3 y of age.DESIGN: Frequent weight and height measurements for 311 Danish children in the SKOT (Complementary and Young Child Feeding - Impact on Short and Long Term Development and Health; in Danish) cohort were used to estimate BMI growth curves for the age span from 14 d to 19 mo by using a nonlinear mixed-effects model. BMI growth velocity before peak and age and BMI at peak were derived from the subject-specific models. Information about pregnancy and breastfeeding was assessed from background questionnaires. Assessment of body composition at age 3 y was made based on bioelectrical impedance, weight, and height.RESULTS: A longer duration of exclusive breastfeeding was associated with an earlier peak in infant BMI (P = 0.0003) and a lower prepeak velocity (P < 0.0001). BMI level at peak and prepeak velocity was positively associated with fat and fat-free mass at age 3 y (all P < 0.0001), whereas a later age at peak was associated with a lower fat mass, fat mass index, and fat-free mass index at age 3 y (all P < 0.001).CONCLUSIONS: BMI peak characteristics are strongly associated with both duration of exclusive breastfeeding and body composition at 3 y of age. Thus, a better knowledge of characteristics and determinants of the early BMI peak is likely to improve our understanding of early development of obesity.
U2 - 10.3945/ajcn.114.092957
DO - 10.3945/ajcn.114.092957
M3 - Journal article
C2 - 25646329
VL - 101
SP - 319
EP - 325
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 2
ER -
ID: 131460223