Increased cancer incidence among patients with hidradenitis suppurativa - a Danish nationwide register study 1977-2017
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Increased cancer incidence among patients with hidradenitis suppurativa - a Danish nationwide register study 1977-2017. / Andersen, Rune; Rostgaard, Klaus; Pedersen, Ole; Jemec, Gregor Borut Ernst; Hjalgrim, Henrik.
In: Acta oncologica (Stockholm, Sweden), Vol. 63, 2024, p. 220-228.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Increased cancer incidence among patients with hidradenitis suppurativa - a Danish nationwide register study 1977-2017
AU - Andersen, Rune
AU - Rostgaard, Klaus
AU - Pedersen, Ole
AU - Jemec, Gregor Borut Ernst
AU - Hjalgrim, Henrik
PY - 2024
Y1 - 2024
N2 - BACKGROUND: The chronic, inflammatory skin disease hidradenitis suppurativa (HS) (prevalence: 0.5%-1%, diagnostic delay: 7-10 years) primarily arises in younger adults and frequently coincides with autoimmune comorbidities and unhealthy life-styles (smoking and obesity). These factors are known to increase cancer risk, but despite this, information on cancer occurrence among HS patients is scarce. MATERIALS AND METHODS: A nationwide retrospective register-based study assessing relative risk of cancer - overall and by anatomical site - following HS diagnosis expressed as standardized incidence ratios (SIRs), which is ratios between observed cases among all Danes diagnosed with HS since 1977 and expected cases based on cancer incidence rates of the entire Danish population during the same period. RESULTS: Participants consisted of a cohort of 13,919 Danes with HS, who during an average of 14.2 years of follow-up developed a total of 1,193 incident cancers, corresponding to a 40% increased risk (SIR = 1.4, 95% CI: 1.3 to 1.4, p < 0.001). Increased risks were observed for cancers of the respiratory system, oral cavity and pharynx, digestive organs and peritoneum, urinary tract, and the lymphatic tissues. INTERPRETATION: These findings underline an unmet need for health monitoring, lifestyle interventions and cancer screening if and when relevant.
AB - BACKGROUND: The chronic, inflammatory skin disease hidradenitis suppurativa (HS) (prevalence: 0.5%-1%, diagnostic delay: 7-10 years) primarily arises in younger adults and frequently coincides with autoimmune comorbidities and unhealthy life-styles (smoking and obesity). These factors are known to increase cancer risk, but despite this, information on cancer occurrence among HS patients is scarce. MATERIALS AND METHODS: A nationwide retrospective register-based study assessing relative risk of cancer - overall and by anatomical site - following HS diagnosis expressed as standardized incidence ratios (SIRs), which is ratios between observed cases among all Danes diagnosed with HS since 1977 and expected cases based on cancer incidence rates of the entire Danish population during the same period. RESULTS: Participants consisted of a cohort of 13,919 Danes with HS, who during an average of 14.2 years of follow-up developed a total of 1,193 incident cancers, corresponding to a 40% increased risk (SIR = 1.4, 95% CI: 1.3 to 1.4, p < 0.001). Increased risks were observed for cancers of the respiratory system, oral cavity and pharynx, digestive organs and peritoneum, urinary tract, and the lymphatic tissues. INTERPRETATION: These findings underline an unmet need for health monitoring, lifestyle interventions and cancer screening if and when relevant.
U2 - 10.2340/1651-226X.2024.26182
DO - 10.2340/1651-226X.2024.26182
M3 - Journal article
C2 - 38647025
AN - SCOPUS:85191411454
VL - 63
SP - 220
EP - 228
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
ER -
ID: 391210646