In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer

In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer: A Nationwide Cohort Study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer : A Nationwide Cohort Study. / Mørch, Lina Steinrud; Gamborg, Mads; Hemmingsen, Caroline Hallas; Skovlund, Charlotte Wessel; Kjær, Susanne Krüger; Hargreave, Marie.

In: Cancers, Vol. 15, No. 12, 3163, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mørch, LS, Gamborg, M, Hemmingsen, CH, Skovlund, CW, Kjær, SK & Hargreave, M 2023, 'In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer: A Nationwide Cohort Study', Cancers, vol. 15, no. 12, 3163. https://doi.org/10.3390/cancers15123163

APA

Mørch, L. S., Gamborg, M., Hemmingsen, C. H., Skovlund, C. W., Kjær, S. K., & Hargreave, M. (2023). In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer: A Nationwide Cohort Study. Cancers, 15(12), [3163]. https://doi.org/10.3390/cancers15123163

Vancouver

Mørch LS, Gamborg M, Hemmingsen CH, Skovlund CW, Kjær SK, Hargreave M. In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer: A Nationwide Cohort Study. Cancers. 2023;15(12). 3163. https://doi.org/10.3390/cancers15123163

Author

Mørch, Lina Steinrud ; Gamborg, Mads ; Hemmingsen, Caroline Hallas ; Skovlund, Charlotte Wessel ; Kjær, Susanne Krüger ; Hargreave, Marie. / In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer : A Nationwide Cohort Study. In: Cancers. 2023 ; Vol. 15, No. 12.

Bibtex

@article{c429b1f7fd40496a91537c7a71ac4798,

title = "In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer: A Nationwide Cohort Study",

abstract = "Approximately 400 million women of reproductive age use hormonal contraceptives worldwide. Eventually, pregnancy sometimes occurs due to irregular use. Use in early pregnancy is found to be associated with child morbidities including cancer, the main reason for disease-related death in children. Here, we add the missing piece about in utero exposure to hormonal contraception and mortality in offspring, including assessments of prognosis in children with cancer. In utero exposure to hormonal contraception may be associated with death since we found a hazard ratio (HR) of 1.22 (95% confidence interval (CI) 1.01–1.48) compared to children of mothers with previous use. The HRs were 1.22 (95% CI 0.99–1.13) for oral combined products and 2.92 (95% CI 1.21–7.04) for non-oral progestin-only products. A poorer prognosis was also found in exposed children with leukemia (3.62 (95% CI: 1.33–9.87)). If causal, hormonal contraception in pregnancy seems detrimental for offspring health and a marker of poorer prognosis in children with leukemia.",

keywords = "child mortality, childhood cancer, hormonal contraception, in utero exposure, pharmacoepidemiology, prognosis",

author = "M{\o}rch, {Lina Steinrud} and Mads Gamborg and Hemmingsen, {Caroline Hallas} and Skovlund, {Charlotte Wessel} and Kj{\ae}r, {Susanne Kr{\"u}ger} and Marie Hargreave",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

doi = "10.3390/cancers15123163",

language = "English",

volume = "15",

journal = "Cancers",

issn = "2072-6694",

publisher = "M D P I AG",

number = "12",

}

RIS

TY - JOUR

T1 - In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer

T2 - A Nationwide Cohort Study

AU - Mørch, Lina Steinrud

AU - Gamborg, Mads

AU - Hemmingsen, Caroline Hallas

AU - Skovlund, Charlotte Wessel

AU - Kjær, Susanne Krüger

AU - Hargreave, Marie

PY - 2023

Y1 - 2023

N2 - Approximately 400 million women of reproductive age use hormonal contraceptives worldwide. Eventually, pregnancy sometimes occurs due to irregular use. Use in early pregnancy is found to be associated with child morbidities including cancer, the main reason for disease-related death in children. Here, we add the missing piece about in utero exposure to hormonal contraception and mortality in offspring, including assessments of prognosis in children with cancer. In utero exposure to hormonal contraception may be associated with death since we found a hazard ratio (HR) of 1.22 (95% confidence interval (CI) 1.01–1.48) compared to children of mothers with previous use. The HRs were 1.22 (95% CI 0.99–1.13) for oral combined products and 2.92 (95% CI 1.21–7.04) for non-oral progestin-only products. A poorer prognosis was also found in exposed children with leukemia (3.62 (95% CI: 1.33–9.87)). If causal, hormonal contraception in pregnancy seems detrimental for offspring health and a marker of poorer prognosis in children with leukemia.

AB - Approximately 400 million women of reproductive age use hormonal contraceptives worldwide. Eventually, pregnancy sometimes occurs due to irregular use. Use in early pregnancy is found to be associated with child morbidities including cancer, the main reason for disease-related death in children. Here, we add the missing piece about in utero exposure to hormonal contraception and mortality in offspring, including assessments of prognosis in children with cancer. In utero exposure to hormonal contraception may be associated with death since we found a hazard ratio (HR) of 1.22 (95% confidence interval (CI) 1.01–1.48) compared to children of mothers with previous use. The HRs were 1.22 (95% CI 0.99–1.13) for oral combined products and 2.92 (95% CI 1.21–7.04) for non-oral progestin-only products. A poorer prognosis was also found in exposed children with leukemia (3.62 (95% CI: 1.33–9.87)). If causal, hormonal contraception in pregnancy seems detrimental for offspring health and a marker of poorer prognosis in children with leukemia.

KW - child mortality

KW - childhood cancer

KW - hormonal contraception

KW - in utero exposure

KW - pharmacoepidemiology

KW - prognosis

U2 - 10.3390/cancers15123163

DO - 10.3390/cancers15123163

M3 - Journal article

C2 - 37370773

AN - SCOPUS:85163886896

VL - 15

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 12

M1 - 3163

ER -

ID: 373548450