Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark
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Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark. / Torp-Pedersen, C; Hildebrandt, P; Køber, L; Nielsen, F E; Jensen, G; Melchior, T; Joen, T; Ringsdal, V; Nielsen, U; Ege, M.
In: European Heart Journal, Vol. 16, No. 1, 1995, p. 14-20.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark
AU - Torp-Pedersen, C
AU - Hildebrandt, P
AU - Køber, L
AU - Nielsen, F E
AU - Jensen, G
AU - Melchior, T
AU - Joen, T
AU - Ringsdal, V
AU - Nielsen, U
AU - Ege, M
N1 - Keywords: Acute Disease; Adult; Aged; Aged, 80 and over; Denmark; Humans; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Retrospective Studies; Risk Factors; Survival Rate; Thrombolytic Therapy
PY - 1995
Y1 - 1995
N2 - The aim of this investigation was to study secular trends in long-term survival following myocardial infarction (MI). Five thousand one hundred and fifty-seven consecutive cases of MI in 3942 patients were recorded in a well-defined region in the study period 1977-1988. The study period ended before thrombolytic therapy was introduced in the hospital. One and 5-year survival (+/- 95% confidence limits) was 61 +/- 2% and 42 +/- 2% in 1977-1980. These figures changed to 61 +/- 2% and 44 +/- 2% in 1981-1984, and to 64 +/- 2 and 46 +/- 2% in 1985-1988. The improvement with time was statistically significant (P < 0.001). In a Cox proportional hazard model, time of infarction was an independent predictor of survival. Patients were subdivided into a high risk group suffering from either congestive heart failure or cardiac arrest during hospitalization, and a low risk group without these complications. Year of infarction was without importance in the high risk group but highly significant in the low risk group. Long-term survival following MI gradually improved prior to the introduction of thrombolytic therapy. The improvement was confined to low risk patients without cardiac arrest or congestive heart failure.
AB - The aim of this investigation was to study secular trends in long-term survival following myocardial infarction (MI). Five thousand one hundred and fifty-seven consecutive cases of MI in 3942 patients were recorded in a well-defined region in the study period 1977-1988. The study period ended before thrombolytic therapy was introduced in the hospital. One and 5-year survival (+/- 95% confidence limits) was 61 +/- 2% and 42 +/- 2% in 1977-1980. These figures changed to 61 +/- 2% and 44 +/- 2% in 1981-1984, and to 64 +/- 2 and 46 +/- 2% in 1985-1988. The improvement with time was statistically significant (P < 0.001). In a Cox proportional hazard model, time of infarction was an independent predictor of survival. Patients were subdivided into a high risk group suffering from either congestive heart failure or cardiac arrest during hospitalization, and a low risk group without these complications. Year of infarction was without importance in the high risk group but highly significant in the low risk group. Long-term survival following MI gradually improved prior to the introduction of thrombolytic therapy. The improvement was confined to low risk patients without cardiac arrest or congestive heart failure.
M3 - Journal article
C2 - 7737214
VL - 16
SP - 14
EP - 20
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 1
ER -
ID: 17422375