Important options available--from start to finish--for translating proteomics results to clinical chemistry
Research output: Contribution to journal › Review › Research › peer-review
Standard
Important options available--from start to finish--for translating proteomics results to clinical chemistry. / Heegaard, Niels H H; Østergaard, Ole; Bahl, Justyna M C; Overgaard, Martin; Beck, Hans C; Rasmussen, Lars Melholt; Larsen, Martin Røssel.
In: Proteomics - Clinical Applications, Vol. 9, No. 1-2, 2015, p. 235-252.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Important options available--from start to finish--for translating proteomics results to clinical chemistry
AU - Heegaard, Niels H H
AU - Østergaard, Ole
AU - Bahl, Justyna M C
AU - Overgaard, Martin
AU - Beck, Hans C
AU - Rasmussen, Lars Melholt
AU - Larsen, Martin Røssel
N1 - © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015
Y1 - 2015
N2 - In the realm of clinical chemistry, the field of clinical proteomics, that is, the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feeds assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry.
AB - In the realm of clinical chemistry, the field of clinical proteomics, that is, the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feeds assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry.
KW - Biomarkers/analysis
KW - Clinical Medicine
KW - Humans
KW - Proteome/analysis
KW - Proteomics/methods
U2 - 10.1002/prca.201400137
DO - 10.1002/prca.201400137
M3 - Review
C2 - 25472910
VL - 9
SP - 235
EP - 252
JO - Proteomics - Clinical Applications
JF - Proteomics - Clinical Applications
SN - 1862-8346
IS - 1-2
ER -
ID: 210474533