Impaired feedback of gastric functions in carboxypeptidase E-deficient mice
Research output: Contribution to journal › Journal article › Research › peer-review
Carboxypeptidase E deficiency as seen in the fat/fat mice is associated with reduced antral somatostatin content but tripling of the progastrin product. Thus, fat/fat mice are able to maintain normal tissue concentrations of bioactive a-amidated gastrin in spite of grossly attenuated progastrin processing. After induction of achlorhydria, however, neither the amount of a-amidated gastrin nor the total progastrin product increased in the fat/fat mice. This is contrary to what is seen in wild-type mice. Furthermore, the synthesis of antral somatostatin and fundic chromogranin A is also abnormal. Hence the results suggest a breakdown in the feedback loop that regulates gastric acid secretion. (C) 2000 Academic Press.
Original language | English |
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Journal | Biochemical and Biophysical Research Communications |
Volume | 267 |
Issue number | 2 |
Pages (from-to) | 638-642 |
Number of pages | 5 |
ISSN | 0006-291X |
DOIs | |
Publication status | Published - 19 Jan 2000 |
ID: 310767307