Impact of menstrual function on hormonal response to repeated bouts of intense exercise
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Impact of menstrual function on hormonal response to repeated bouts of intense exercise. / Melin, Anna K.; Ritz, Christian; Faber, Jens; Skouby, Sven; Pingel, Jessica; Sundgot-Borgen, Jorunn; Sjödin, Anders Mikael; Tornberg, Åsa B.
In: Frontiers in Physiology, Vol. 10, 942, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of menstrual function on hormonal response to repeated bouts of intense exercise
AU - Melin, Anna K.
AU - Ritz, Christian
AU - Faber, Jens
AU - Skouby, Sven
AU - Pingel, Jessica
AU - Sundgot-Borgen, Jorunn
AU - Sjödin, Anders Mikael
AU - Tornberg, Åsa B
N1 - CURIS 2019 NEXS 264
PY - 2019
Y1 - 2019
N2 - Background: Strenous exercise stimulates the hypothalamic-pituitary (HP) axis inorder to ensure homeostasis and promote anabolism. Furthermore, exercise stimulates a transient increase in the neurotrophin brain-derived neurotrophic factor (BDNF) suggested to mediate the anxiolytic effects of exercise. Athletes with secondary functional hypothalamic amenorrhea (FHA) have been reported to have lower BDNF, and a blunted HP axis response to exercise as athletes with overtraining syndrome.Aim: The aim of the study was to investigate the hormonal and BDNF responses to a two-bout maximal exercise protocol with four hours of recovery in between in FHA and eumenorrheic (EUM) athletes.Methods: Eumenorrheic (n = 16) and FHA (n = 14) endurance athletes wererecruited from national teams and competitive clubs. Protocols included gynecological examination; body composition (DXA); 7-day assessment of energy availability; blood sampling pre and post the two exercises tests.Results: There were no differences between groups in hormonal responses to thefirst exercise bout. After the second exercise bout IGFBP-3 increased more in FHA compared with EUM athletes (2.1 0.5 vs. 0.6 0.6 mg/L, p = 0.048). There were non-significant trends toward higher increase in IGF-1 (39.3 4.3 vs. 28.0 4.6 mg/L, p = 0.074), BDNF (96.5 22.9 vs. 34.4 23.5 mg/L, p = 0.058), GH to cortisol ratio (0.329 0.010 vs. 0.058 0.010, p = 0.082), and decrease in IGF-1 to IGFBP-3 ratio (2.04 1.2 vs. 0.92 1.22, p = 0.081) in athletes with FHA compared with EUM athletes. Furthermore, there was a non-significant trend toward a higher increase in prolactin to cortisol ratio in EUM athletes compared with athletes with FHA (0.60 0.15 vs. 0.23 0.15, p = 0.071). No differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function were found.Conclusion: No major differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function could be detected.
AB - Background: Strenous exercise stimulates the hypothalamic-pituitary (HP) axis inorder to ensure homeostasis and promote anabolism. Furthermore, exercise stimulates a transient increase in the neurotrophin brain-derived neurotrophic factor (BDNF) suggested to mediate the anxiolytic effects of exercise. Athletes with secondary functional hypothalamic amenorrhea (FHA) have been reported to have lower BDNF, and a blunted HP axis response to exercise as athletes with overtraining syndrome.Aim: The aim of the study was to investigate the hormonal and BDNF responses to a two-bout maximal exercise protocol with four hours of recovery in between in FHA and eumenorrheic (EUM) athletes.Methods: Eumenorrheic (n = 16) and FHA (n = 14) endurance athletes wererecruited from national teams and competitive clubs. Protocols included gynecological examination; body composition (DXA); 7-day assessment of energy availability; blood sampling pre and post the two exercises tests.Results: There were no differences between groups in hormonal responses to thefirst exercise bout. After the second exercise bout IGFBP-3 increased more in FHA compared with EUM athletes (2.1 0.5 vs. 0.6 0.6 mg/L, p = 0.048). There were non-significant trends toward higher increase in IGF-1 (39.3 4.3 vs. 28.0 4.6 mg/L, p = 0.074), BDNF (96.5 22.9 vs. 34.4 23.5 mg/L, p = 0.058), GH to cortisol ratio (0.329 0.010 vs. 0.058 0.010, p = 0.082), and decrease in IGF-1 to IGFBP-3 ratio (2.04 1.2 vs. 0.92 1.22, p = 0.081) in athletes with FHA compared with EUM athletes. Furthermore, there was a non-significant trend toward a higher increase in prolactin to cortisol ratio in EUM athletes compared with athletes with FHA (0.60 0.15 vs. 0.23 0.15, p = 0.071). No differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function were found.Conclusion: No major differences in the hormonal or BDNF responses between the two exercise bouts as a result of menstrual function could be detected.
KW - Amenorrhea
KW - Energy availability
KW - Overtraining syndrome
KW - Female athlete
KW - Brain derived neuronal factor
U2 - 10.3389/fphys.2019.00942
DO - 10.3389/fphys.2019.00942
M3 - Journal article
C2 - 31417414
VL - 10
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
M1 - 942
ER -
ID: 225553781