IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease?
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease? / Parlesak, Alexandr; Schäfer, Christian; Bode, Christiane.
In: Digestive Diseases and Sciences, Vol. 47, No. 4, 2002, p. 760-766.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - IgA against gut-derived endotoxins: Does it contribute to suppression of hepatic inflammation in alcohol-induced liver disease?
AU - Parlesak, Alexandr
AU - Schäfer, Christian
AU - Bode, Christiane
N1 - (Ekstern)
PY - 2002
Y1 - 2002
N2 - Endotoxins of intestinal origin are supposed to play an important role in the development of alcoholic hepatitis in man. To estimate the role of immunoglobulin response to gut-derived endotoxin in the development of alcohol-induced liver disease, serum levels of IgA and IgG against fecal endotoxin, endotoxin, and acute-phase proteins were measured in patients with different stages of alcoholic liver disease and in healthy controls. Antibodies of type IgA, but not IgG, against fecal endotoxins were significantly increased in patients with alcohol-induced liver disease. IgA antibodies against fecal endotoxin were found to be closely correlated with the plasma concentrations of alanine aminotransferase, γ-glutamyl transferase, and C-reactive protein in patients with alcoholic liver disease. In conclusion, as IgA located in body tissue was shown to suppress the inflammatory process, enhanced production of IgA against endotoxin of intestinal origin may contribute to inactivation of this compound, thereby reducing its damaging effect on the liver.
AB - Endotoxins of intestinal origin are supposed to play an important role in the development of alcoholic hepatitis in man. To estimate the role of immunoglobulin response to gut-derived endotoxin in the development of alcohol-induced liver disease, serum levels of IgA and IgG against fecal endotoxin, endotoxin, and acute-phase proteins were measured in patients with different stages of alcoholic liver disease and in healthy controls. Antibodies of type IgA, but not IgG, against fecal endotoxins were significantly increased in patients with alcohol-induced liver disease. IgA antibodies against fecal endotoxin were found to be closely correlated with the plasma concentrations of alanine aminotransferase, γ-glutamyl transferase, and C-reactive protein in patients with alcoholic liver disease. In conclusion, as IgA located in body tissue was shown to suppress the inflammatory process, enhanced production of IgA against endotoxin of intestinal origin may contribute to inactivation of this compound, thereby reducing its damaging effect on the liver.
U2 - 10.1023/A:1014783815433
DO - 10.1023/A:1014783815433
M3 - Journal article
VL - 47
SP - 760
EP - 766
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 4
ER -
ID: 317459658