Hypokalemia and rhabdomyolysis
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Hypokalemia and rhabdomyolysis. / Horwitz, Henrik; Woeien, Vidar A.; Petersen, Linda Wiuff; Jimenez-Solem, Espen.
In: Journal of Pharmacology and Pharmacotherapeutics, Vol. 6, No. 2, 01.04.2015, p. 98-99.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Hypokalemia and rhabdomyolysis
AU - Horwitz, Henrik
AU - Woeien, Vidar A.
AU - Petersen, Linda Wiuff
AU - Jimenez-Solem, Espen
PY - 2015/4/1
Y1 - 2015/4/1
N2 - The adverse drug event manager of the Capital Region of Denmark received a report of a 65-year-old male with type II diabetes and long-lasting treatment with indapamide. In addition, he had a history of a high consumption of licorice. For 2 weeks, the patient suffered from myalgia, which the general practitioner suspected to be polymyalgia rheumatica and referred him to the hospital. Initial blood samples revealed a reduced potassium concentration of 1.5 mmol/L (reference value: 6.6-4.6 mmol/L) and an elevated creatine kinase of 18,400 IU/L (reference value: 40-280 IU/L). We believe that the patient developed rhabdomyolysis due to severe hypokalemia, possibly induced by a pharmacodynamic interaction between licorice and indapamide.
AB - The adverse drug event manager of the Capital Region of Denmark received a report of a 65-year-old male with type II diabetes and long-lasting treatment with indapamide. In addition, he had a history of a high consumption of licorice. For 2 weeks, the patient suffered from myalgia, which the general practitioner suspected to be polymyalgia rheumatica and referred him to the hospital. Initial blood samples revealed a reduced potassium concentration of 1.5 mmol/L (reference value: 6.6-4.6 mmol/L) and an elevated creatine kinase of 18,400 IU/L (reference value: 40-280 IU/L). We believe that the patient developed rhabdomyolysis due to severe hypokalemia, possibly induced by a pharmacodynamic interaction between licorice and indapamide.
KW - Hypokalemia
KW - indapamide
KW - licorice
KW - rhabdomyolysis
KW - side-effects
UR - http://www.scopus.com/inward/record.url?scp=84928641474&partnerID=8YFLogxK
U2 - 10.4103/0976-500X.155488
DO - 10.4103/0976-500X.155488
M3 - Journal article
AN - SCOPUS:84928641474
VL - 6
SP - 98
EP - 99
JO - Journal of Pharmacology and Pharmacotherapeutics
JF - Journal of Pharmacology and Pharmacotherapeutics
SN - 0976-500X
IS - 2
ER -
ID: 389911363