TY - JOUR

T1 - Hypertension, cardiovascular disease and cause of death in Danish living kidney donors

T2 - Matched cohort study

AU - Chaudry, Mavish

AU - Gislason, Gunnar Hilmar

AU - Fosbøl, Emil Loldrup

AU - Køber, Lars

AU - Gerds, Thomas Alexander

AU - Torp-Pedersen, Christian

PY - 2020

Y1 - 2020

N2 - Objectives: We aimed to investigate the long-term absolute risk of hypertension and cardiovascular disease after kidney donation in living kidney donors. Design: Living kidney donors were matched to 10 controls from the general population. Setting: Multiple Danish national registries were used to identify living kidney donors from 1 January 1996 to 31 December 2017 nationwide. Participants: 1262 living kidney donors and 12 620 controls. Main outcome measures Hypertension, cardiovascular disease and diabetes. Results: The median age of living kidney donors was 52 (men 43%). Hypertension developed in 50 (4%) and 231 (1.8%) with a median follow-up of 7 years (IQR 3.3-12.1 years with a maximum follow-up of 22 years) and 6.9 years (IQR 3.2-11.7 years and maximum follow-up of 22 years) for donors and controls, respectively. The absolute risk of hypertension was 2.3% (95% CI 1.4% to 3.2%) and 1.2% (95% CI 1.0% to 1.4%), 4.2% (95% CI 2.8% to 5.7%) and 2.4% (95% CI 2.1% to 2.8%), 8.6% (95% CI 6.0% to 11.3%) and 3.3% (95% CI 2.8% to 3.8%) within 5, 10, 15 years for donors and controls, respectively. The ratio of the 10-year absolute risks for hypertension was 1.64 (95% CI 1.44 to 1.88) for donors compared with the controls. Two donors and four controls developed renal replacement therapy requiring end-stage renal disease during follow-up. The absolute risk of cardiovascular disease and diabetes was 7.3% (95% CI 5.7% to 9.5%) and 8.3% (95% CI 7.7% to 9.0%), 1.7% (95% CI 0.7% to 2.8%) and 3.2% (95% CI 2.7% to 3.6%) at 10 years for donors and controls, respectively. Conclusions: Living kidney donors have an increased long-term absolute risk of hypertension compared with controls from the general population.

AB - Objectives: We aimed to investigate the long-term absolute risk of hypertension and cardiovascular disease after kidney donation in living kidney donors. Design: Living kidney donors were matched to 10 controls from the general population. Setting: Multiple Danish national registries were used to identify living kidney donors from 1 January 1996 to 31 December 2017 nationwide. Participants: 1262 living kidney donors and 12 620 controls. Main outcome measures Hypertension, cardiovascular disease and diabetes. Results: The median age of living kidney donors was 52 (men 43%). Hypertension developed in 50 (4%) and 231 (1.8%) with a median follow-up of 7 years (IQR 3.3-12.1 years with a maximum follow-up of 22 years) and 6.9 years (IQR 3.2-11.7 years and maximum follow-up of 22 years) for donors and controls, respectively. The absolute risk of hypertension was 2.3% (95% CI 1.4% to 3.2%) and 1.2% (95% CI 1.0% to 1.4%), 4.2% (95% CI 2.8% to 5.7%) and 2.4% (95% CI 2.1% to 2.8%), 8.6% (95% CI 6.0% to 11.3%) and 3.3% (95% CI 2.8% to 3.8%) within 5, 10, 15 years for donors and controls, respectively. The ratio of the 10-year absolute risks for hypertension was 1.64 (95% CI 1.44 to 1.88) for donors compared with the controls. Two donors and four controls developed renal replacement therapy requiring end-stage renal disease during follow-up. The absolute risk of cardiovascular disease and diabetes was 7.3% (95% CI 5.7% to 9.5%) and 8.3% (95% CI 7.7% to 9.0%), 1.7% (95% CI 0.7% to 2.8%) and 3.2% (95% CI 2.7% to 3.6%) at 10 years for donors and controls, respectively. Conclusions: Living kidney donors have an increased long-term absolute risk of hypertension compared with controls from the general population.

KW - cardiology

KW - hypertension

KW - renal transplantation

U2 - 10.1136/bmjopen-2020-041122

DO - 10.1136/bmjopen-2020-041122

M3 - Journal article

C2 - 33168561

AN - SCOPUS:85095962104

VL - 10

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 11

M1 - e041122

ER -