Human serum albumin and immunoglobulin on Dracunculus medinensis
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Human serum albumin and immunoglobulin on Dracunculus medinensis. / Bloch, P; Lund, M; Vennervald, B J; Simonsen, Paul Erik.
In: Acta Tropica, Vol. 73, No. 2, 30.07.1999, p. 135-41.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Human serum albumin and immunoglobulin on Dracunculus medinensis
AU - Bloch, P
AU - Lund, M
AU - Vennervald, B J
AU - Simonsen, Paul Erik
PY - 1999/7/30
Y1 - 1999/7/30
N2 - Dracunculus medinensis recovered from infected humans were examined for the occurrence and localization of human serum albumin and immunoglobulins. Immunoelectrophoretic examination of homogenates prepared from adult female worms (ADGW) and first stage larvae (LVGW) showed that anti-human albumin antibodies reacted to both stages of the parasite. By direct fluorescence antibody technique, antigens resembling human albumin and human immunoglobulins (isotype IgG) were identified on the surface of adult female worms. The occurrence of host-like compounds on the parasites may be an adaptation for survival of the parasites. A possible interference of these compounds should be considered in attempts to develop methods for immunological diagnosis of D. medinensis infections.
AB - Dracunculus medinensis recovered from infected humans were examined for the occurrence and localization of human serum albumin and immunoglobulins. Immunoelectrophoretic examination of homogenates prepared from adult female worms (ADGW) and first stage larvae (LVGW) showed that anti-human albumin antibodies reacted to both stages of the parasite. By direct fluorescence antibody technique, antigens resembling human albumin and human immunoglobulins (isotype IgG) were identified on the surface of adult female worms. The occurrence of host-like compounds on the parasites may be an adaptation for survival of the parasites. A possible interference of these compounds should be considered in attempts to develop methods for immunological diagnosis of D. medinensis infections.
M3 - Journal article
C2 - 10465053
VL - 73
SP - 135
EP - 141
JO - Acta Tropica
JF - Acta Tropica
SN - 0001-706X
IS - 2
ER -
ID: 32352656