Human migraine models
Research output: Contribution to journal › Journal article › Research › peer-review
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Human migraine models. / Iversen, Helle Klingenberg.
In: Cephalalgia : an international journal of headache, Vol. 21, No. 7, 09.2001, p. 781-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Human migraine models
AU - Iversen, Helle Klingenberg
PY - 2001/9
Y1 - 2001/9
N2 - The need for experimental models is obvious. In animal models it is possible to study vascular responses, neurogenic inflammation, c-fos expression etc. However, the pathophysiology of migraine remains unsolved, why results from animal studies not directly can be related to the migraine attack, which is a human experience. A set-up for investigations of experimental headache and migraine in humans, has been evaluated and headache mechanisms explored by using nitroglycerin and other headache-inducing agents. Nitric oxide (NO) or other parts of the NO activated cascade seems to be responsible for the induced headache and migraine. Perspectives are discussed.
AB - The need for experimental models is obvious. In animal models it is possible to study vascular responses, neurogenic inflammation, c-fos expression etc. However, the pathophysiology of migraine remains unsolved, why results from animal studies not directly can be related to the migraine attack, which is a human experience. A set-up for investigations of experimental headache and migraine in humans, has been evaluated and headache mechanisms explored by using nitroglycerin and other headache-inducing agents. Nitric oxide (NO) or other parts of the NO activated cascade seems to be responsible for the induced headache and migraine. Perspectives are discussed.
KW - Animals
KW - Cerebrovascular Circulation
KW - Humans
KW - Migraine Disorders
KW - Models, Neurological
KW - Nitroglycerin
KW - Vasodilator Agents
M3 - Journal article
C2 - 11595013
VL - 21
SP - 781
EP - 785
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 7
ER -
ID: 128983639