Heart and Lung Dose as Predictors of Overall Survival in Patients With Locally Advanced Lung Cancer. A National Multicenter Study
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Heart and Lung Dose as Predictors of Overall Survival in Patients With Locally Advanced Lung Cancer. A National Multicenter Study. / Olloni, Agon; Brink, Carsten; Lorenzen, Ebbe Laugaard; Jeppesen, Stefan Starup; Hofmann, Lone; Kristiansen, Charlotte; Knap, Marianne Marquard; Møller, Ditte Sloth; Nygård, Lotte; Persson, Gitte Fredberg; Thing, Rune Slot; Sand, Hella Maria Brøgger; Diederichsen, Axel; Schytte, Tine.
In: JTO Clinical and Research Reports, Vol. 5, No. 4, 100663, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Heart and Lung Dose as Predictors of Overall Survival in Patients With Locally Advanced Lung Cancer. A National Multicenter Study
AU - Olloni, Agon
AU - Brink, Carsten
AU - Lorenzen, Ebbe Laugaard
AU - Jeppesen, Stefan Starup
AU - Hofmann, Lone
AU - Kristiansen, Charlotte
AU - Knap, Marianne Marquard
AU - Møller, Ditte Sloth
AU - Nygård, Lotte
AU - Persson, Gitte Fredberg
AU - Thing, Rune Slot
AU - Sand, Hella Maria Brøgger
AU - Diederichsen, Axel
AU - Schytte, Tine
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Introduction: It is an ongoing debate how much lung and heart irradiation impact overall survival (OS) after definitive radiotherapy for lung cancer. This study uses a large national cohort of patients with locally advanced NSCLC to investigate the association between OS and irradiation of lung and heart. Methods: Treatment plans were acquired from six Danish radiotherapy centers, and patient characteristics were obtained from national registries. A hybrid segmentation tool automatically delineated the heart and substructures. Dose-volume histograms for all structures were extracted and analyzed using principal component analyses (PCAs). Parameter selection for a multivariable Cox model for OS prediction was performed using cross-validation based on bootstrapping. Results: The population consisted of 644 patients with a median survival of 26 months (95% confidence interval [CI]: 24–29). The cross-validation selected two PCA variables to be included in the multivariable model. PCA1 represented irradiation of the heart and affected OS negatively (hazard ratio, 1.14; 95% CI: 1.04–1.26). PCA2 characterized the left-right balance (right atrium and left ventricle) irradiation, showing better survival for tumors near the right side (hazard ratio, 0.92; 95% CI: 0.84–1.00). Besides the two PCA variables, the multivariable model included age, sex, body-mass index, performance status, tumor dose, and tumor volume. Conclusions: Besides the classic noncardiac risk factors, lung and heart doses had a negative impact on survival, while it is suggested that the left side of the heart is a more radiation dose–sensitive region. The data indicate that overall heart irradiation should be reduced to improve the OS if possible.
AB - Introduction: It is an ongoing debate how much lung and heart irradiation impact overall survival (OS) after definitive radiotherapy for lung cancer. This study uses a large national cohort of patients with locally advanced NSCLC to investigate the association between OS and irradiation of lung and heart. Methods: Treatment plans were acquired from six Danish radiotherapy centers, and patient characteristics were obtained from national registries. A hybrid segmentation tool automatically delineated the heart and substructures. Dose-volume histograms for all structures were extracted and analyzed using principal component analyses (PCAs). Parameter selection for a multivariable Cox model for OS prediction was performed using cross-validation based on bootstrapping. Results: The population consisted of 644 patients with a median survival of 26 months (95% confidence interval [CI]: 24–29). The cross-validation selected two PCA variables to be included in the multivariable model. PCA1 represented irradiation of the heart and affected OS negatively (hazard ratio, 1.14; 95% CI: 1.04–1.26). PCA2 characterized the left-right balance (right atrium and left ventricle) irradiation, showing better survival for tumors near the right side (hazard ratio, 0.92; 95% CI: 0.84–1.00). Besides the two PCA variables, the multivariable model included age, sex, body-mass index, performance status, tumor dose, and tumor volume. Conclusions: Besides the classic noncardiac risk factors, lung and heart doses had a negative impact on survival, while it is suggested that the left side of the heart is a more radiation dose–sensitive region. The data indicate that overall heart irradiation should be reduced to improve the OS if possible.
KW - Definitive radiotherapy
KW - Dose to heart chambers and coronary arteries
KW - Heart dose
KW - Lung dose
KW - NSCLC
KW - Overall survival
U2 - 10.1016/j.jtocrr.2024.100663
DO - 10.1016/j.jtocrr.2024.100663
M3 - Journal article
C2 - 38590728
AN - SCOPUS:85189132950
VL - 5
JO - JTO Clinical and Research Reports
JF - JTO Clinical and Research Reports
SN - 2666-3643
IS - 4
M1 - 100663
ER -
ID: 387979791