Health promoting compounds in vegetables and fruits: A systematic approach for identifying plant components with impact on human health
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Health promoting compounds in vegetables and fruits : A systematic approach for identifying plant components with impact on human health. / Brandt, K.; Christensen, L. P.; Hansen-Møller, J.; Hansen, S. L.; Haraldsdottir, J.; Jespersen, L.; Purup, S.; Kharazmi, A.; Barkholt, V.; Frøkiær, H.; Kobæk-Larsen, M.
In: Trends in Food Science and Technology, Vol. 15, No. 7-8, 07.2004, p. 384-393.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Health promoting compounds in vegetables and fruits
T2 - A systematic approach for identifying plant components with impact on human health
AU - Brandt, K.
AU - Christensen, L. P.
AU - Hansen-Møller, J.
AU - Hansen, S. L.
AU - Haraldsdottir, J.
AU - Jespersen, L.
AU - Purup, S.
AU - Kharazmi, A.
AU - Barkholt, V.
AU - Frøkiær, H.
AU - Kobæk-Larsen, M.
N1 - Funding Information: The support of the Danish Research Council for Agricultural and Veterinary Research, Danish Food Technology Initiative (FØTEK 3) grant no. 2011-00-0040, is gratefully acknowledged.
PY - 2004/7
Y1 - 2004/7
N2 - Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicity at high concentrations or other bioactivity; and 1.3, presence in healthy foods. Step 2 is testing for minimum criteria defining health-promoting compounds: 2.1, positive or biphasic ("hormesis") responses in bioassay; 2.2, human tissue concentrations corresponding to beneficial effects in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats.
AB - Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicity at high concentrations or other bioactivity; and 1.3, presence in healthy foods. Step 2 is testing for minimum criteria defining health-promoting compounds: 2.1, positive or biphasic ("hormesis") responses in bioassay; 2.2, human tissue concentrations corresponding to beneficial effects in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats.
UR - http://www.scopus.com/inward/record.url?scp=2342456592&partnerID=8YFLogxK
U2 - 10.1016/j.tifs.2003.12.003
DO - 10.1016/j.tifs.2003.12.003
M3 - Journal article
AN - SCOPUS:2342456592
VL - 15
SP - 384
EP - 393
JO - Trends in Food Science & Technology
JF - Trends in Food Science & Technology
SN - 0924-2244
IS - 7-8
ER -
ID: 316998846