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Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. / Buescher, Joerg Martin; Liebermeister, Wolfram; Jules, Matthieu; Uhr, Markus; Muntel, Jan; Botella, Eric; Hessling, Bernd; Kleijn, Roelco Jacobus; Le Chat, Ludovic; Lecointe, François; Mäder, Ulrike; Nicolas, Pierre; Piersma, Sjouke; Rügheimer, Frank; Becher, Dörte; Bessieres, Philippe; Bidnenko, Elena; Denham, Emma L; Dervyn, Etienne; Devine, Kevin M; Doherty, Geoff; Drulhe, Samuel; Felicori, Liza; Fogg, Mark J; Goelzer, Anne; Hansen, Annette; Harwood, Colin R; Hecker, Michael; Hubner, Sebastian; Hultschig, Claus; Jarmer, Hanne; Klipp, Edda; Leduc, Aurélie; Lewis, Peter; Molina, Frank; Noirot, Philippe; Peres, Sabine; Pigeonneau, Nathalie; Pohl, Susanne; Rasmussen, Simon; Rinn, Bernd; Schaffer, Marc; Schnidder, Julian; Schwikowski, Benno; Van Dijl, Jan Maarten; Veiga, Patrick; Walsh, Sean; Wilkinson, Anthony J; Stelling, Jörg; Aymerich, Stéphane.
In:
Science (New York, N.Y.), Vol. 335, No. 6072, 02.03.2012, p. 1099-103.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Buescher, JM, Liebermeister, W, Jules, M, Uhr, M, Muntel, J, Botella, E, Hessling, B, Kleijn, RJ, Le Chat, L, Lecointe, F, Mäder, U, Nicolas, P, Piersma, S, Rügheimer, F, Becher, D, Bessieres, P, Bidnenko, E, Denham, EL, Dervyn, E, Devine, KM, Doherty, G, Drulhe, S, Felicori, L, Fogg, MJ, Goelzer, A, Hansen, A, Harwood, CR, Hecker, M, Hubner, S, Hultschig, C, Jarmer, H, Klipp, E, Leduc, A, Lewis, P, Molina, F, Noirot, P, Peres, S, Pigeonneau, N, Pohl, S
, Rasmussen, S, Rinn, B, Schaffer, M, Schnidder, J, Schwikowski, B, Van Dijl, JM, Veiga, P, Walsh, S, Wilkinson, AJ, Stelling, J & Aymerich, S 2012, '
Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism',
Science (New York, N.Y.), vol. 335, no. 6072, pp. 1099-103.
https://doi.org/10.1126/science.1206871APA
Buescher, J. M., Liebermeister, W., Jules, M., Uhr, M., Muntel, J., Botella, E., Hessling, B., Kleijn, R. J., Le Chat, L., Lecointe, F., Mäder, U., Nicolas, P., Piersma, S., Rügheimer, F., Becher, D., Bessieres, P., Bidnenko, E., Denham, E. L., Dervyn, E., ... Aymerich, S. (2012).
Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.
Science (New York, N.Y.),
335(6072), 1099-103.
https://doi.org/10.1126/science.1206871Vancouver
Buescher JM, Liebermeister W, Jules M, Uhr M, Muntel J, Botella E et al.
Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism.
Science (New York, N.Y.). 2012 Mar 2;335(6072):1099-103.
https://doi.org/10.1126/science.1206871Author
Buescher, Joerg Martin ; Liebermeister, Wolfram ; Jules, Matthieu ; Uhr, Markus ; Muntel, Jan ; Botella, Eric ; Hessling, Bernd ; Kleijn, Roelco Jacobus ; Le Chat, Ludovic ; Lecointe, François ; Mäder, Ulrike ; Nicolas, Pierre ; Piersma, Sjouke ; Rügheimer, Frank ; Becher, Dörte ; Bessieres, Philippe ; Bidnenko, Elena ; Denham, Emma L ; Dervyn, Etienne ; Devine, Kevin M ; Doherty, Geoff ; Drulhe, Samuel ; Felicori, Liza ; Fogg, Mark J ; Goelzer, Anne ; Hansen, Annette ; Harwood, Colin R ; Hecker, Michael ; Hubner, Sebastian ; Hultschig, Claus ; Jarmer, Hanne ; Klipp, Edda ; Leduc, Aurélie ; Lewis, Peter ; Molina, Frank ; Noirot, Philippe ; Peres, Sabine ; Pigeonneau, Nathalie ; Pohl, Susanne ; Rasmussen, Simon ; Rinn, Bernd ; Schaffer, Marc ; Schnidder, Julian ; Schwikowski, Benno ; Van Dijl, Jan Maarten ; Veiga, Patrick ; Walsh, Sean ; Wilkinson, Anthony J ; Stelling, Jörg ; Aymerich, Stéphane. / Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. In: Science (New York, N.Y.). 2012 ; Vol. 335, No. 6072. pp. 1099-103.
Bibtex
@article{72a573f005604c769af30a2b5400ed66,
title = "Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism",
abstract = "Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.",
keywords = "Adaptation, Physiological, Algorithms, Bacillus subtilis/genetics, Bacterial Proteins/metabolism, Computer Simulation, Data Interpretation, Statistical, Gene Expression Regulation, Bacterial, Gene Regulatory Networks, Genome, Bacterial, Glucose/metabolism, Malates/metabolism, Metabolic Networks and Pathways/genetics, Metabolome, Metabolomics, Models, Biological, Operon, Promoter Regions, Genetic, Transcription Factors/metabolism, Transcription, Genetic",
author = "Buescher, {Joerg Martin} and Wolfram Liebermeister and Matthieu Jules and Markus Uhr and Jan Muntel and Eric Botella and Bernd Hessling and Kleijn, {Roelco Jacobus} and {Le Chat}, Ludovic and Fran{\c c}ois Lecointe and Ulrike M{\"a}der and Pierre Nicolas and Sjouke Piersma and Frank R{\"u}gheimer and D{\"o}rte Becher and Philippe Bessieres and Elena Bidnenko and Denham, {Emma L} and Etienne Dervyn and Devine, {Kevin M} and Geoff Doherty and Samuel Drulhe and Liza Felicori and Fogg, {Mark J} and Anne Goelzer and Annette Hansen and Harwood, {Colin R} and Michael Hecker and Sebastian Hubner and Claus Hultschig and Hanne Jarmer and Edda Klipp and Aur{\'e}lie Leduc and Peter Lewis and Frank Molina and Philippe Noirot and Sabine Peres and Nathalie Pigeonneau and Susanne Pohl and Simon Rasmussen and Bernd Rinn and Marc Schaffer and Julian Schnidder and Benno Schwikowski and {Van Dijl}, {Jan Maarten} and Patrick Veiga and Sean Walsh and Wilkinson, {Anthony J} and J{\"o}rg Stelling and St{\'e}phane Aymerich",
year = "2012",
month = mar,
day = "2",
doi = "10.1126/science.1206871",
language = "English",
volume = "335",
pages = "1099--103",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6072",
}
RIS
TY - JOUR
T1 - Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism
AU - Buescher, Joerg Martin
AU - Liebermeister, Wolfram
AU - Jules, Matthieu
AU - Uhr, Markus
AU - Muntel, Jan
AU - Botella, Eric
AU - Hessling, Bernd
AU - Kleijn, Roelco Jacobus
AU - Le Chat, Ludovic
AU - Lecointe, François
AU - Mäder, Ulrike
AU - Nicolas, Pierre
AU - Piersma, Sjouke
AU - Rügheimer, Frank
AU - Becher, Dörte
AU - Bessieres, Philippe
AU - Bidnenko, Elena
AU - Denham, Emma L
AU - Dervyn, Etienne
AU - Devine, Kevin M
AU - Doherty, Geoff
AU - Drulhe, Samuel
AU - Felicori, Liza
AU - Fogg, Mark J
AU - Goelzer, Anne
AU - Hansen, Annette
AU - Harwood, Colin R
AU - Hecker, Michael
AU - Hubner, Sebastian
AU - Hultschig, Claus
AU - Jarmer, Hanne
AU - Klipp, Edda
AU - Leduc, Aurélie
AU - Lewis, Peter
AU - Molina, Frank
AU - Noirot, Philippe
AU - Peres, Sabine
AU - Pigeonneau, Nathalie
AU - Pohl, Susanne
AU - Rasmussen, Simon
AU - Rinn, Bernd
AU - Schaffer, Marc
AU - Schnidder, Julian
AU - Schwikowski, Benno
AU - Van Dijl, Jan Maarten
AU - Veiga, Patrick
AU - Walsh, Sean
AU - Wilkinson, Anthony J
AU - Stelling, Jörg
AU - Aymerich, Stéphane
PY - 2012/3/2
Y1 - 2012/3/2
N2 - Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.
AB - Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.
KW - Adaptation, Physiological
KW - Algorithms
KW - Bacillus subtilis/genetics
KW - Bacterial Proteins/metabolism
KW - Computer Simulation
KW - Data Interpretation, Statistical
KW - Gene Expression Regulation, Bacterial
KW - Gene Regulatory Networks
KW - Genome, Bacterial
KW - Glucose/metabolism
KW - Malates/metabolism
KW - Metabolic Networks and Pathways/genetics
KW - Metabolome
KW - Metabolomics
KW - Models, Biological
KW - Operon
KW - Promoter Regions, Genetic
KW - Transcription Factors/metabolism
KW - Transcription, Genetic
U2 - 10.1126/science.1206871
DO - 10.1126/science.1206871
M3 - Journal article
C2 - 22383848
VL - 335
SP - 1099
EP - 1103
JO - Science
JF - Science
SN - 0036-8075
IS - 6072
ER -
