Genomic affinities of two 7,000-year-old Iberian hunter-gatherers
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Genomic affinities of two 7,000-year-old Iberian hunter-gatherers. / Sánchez-Quinto, Federico; Schroeder, Hannes; Ramirez, Oscar; Avila Arcos, Maria del Carmen; Pybus, Marc; Olalde, Iñigo; Velazquez, Amhed M. V.; Marcos, María Encina Prada; Encinas, Julio Manuel Vidal; Bertranpetit, Jaume; Orlando, Ludovic Antoine Alexandre; Gilbert, Tom; Lalueza-Fox, Carles.
In: Current Biology, Vol. 22, No. 16, 2012, p. 1494-1499.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genomic affinities of two 7,000-year-old Iberian hunter-gatherers
AU - Sánchez-Quinto, Federico
AU - Schroeder, Hannes
AU - Ramirez, Oscar
AU - Avila Arcos, Maria del Carmen
AU - Pybus, Marc
AU - Olalde, Iñigo
AU - Velazquez, Amhed M. V.
AU - Marcos, María Encina Prada
AU - Encinas, Julio Manuel Vidal
AU - Bertranpetit, Jaume
AU - Orlando, Ludovic Antoine Alexandre
AU - Gilbert, Tom
AU - Lalueza-Fox, Carles
PY - 2012
Y1 - 2012
N2 - The genetic background of the European Mesolithic and the extent of population replacement during the Neolithic [1–10] is poorly understood, both due to the scarcity of human remains from that period [11–18] and the inherent methodological difficulties of ancient DNA research. However, advances in sequencing technologies are both increasing data yields and providing supporting evidence for data authenticity, such as nucleotide misincorporation patterns [19–22]. We use these methods to characterize both the mitochondrial DNA genome and generate shotgun genomic data from two exceptionally well-preserved 7,000-year-old Mesolithic individuals from La Braña-Arintero site in León (Northwestern Spain) [23]. The mitochondria of both individuals are assigned to U5b2c1, a haplotype common among the small number of other previously studied Mesolithic individuals from Northern and Central Europe. This suggests a remarkable genetic uniformity and little phylogeographic structure over a large geographic area of the pre-Neolithic populations. Using Approximate Bayesian Computation, a model of genetic continuity from Mesolithic to Neolithic populations is poorly supported. Furthermore, analyses of 1.34% and 0.53% of their nuclear genomes, containing about 50,000 and 20,000 ancestry informative SNPs, respectively, show that these two Mesolithic individuals are not related to current populations from either the Iberian Peninsula or Southern Europe. Highlights ¿ The first complete Mesolithic mtDNA genome retrieved ¿ There is a remarkable genetic uniformity in Europe during the Mesolithic period ¿ Modern Iberians are not direct descendants of the 7,000-year-old hunter-gatherers ¿ Genetic discontinuity between Mesolithic/Neolithic populations supported by simulations
AB - The genetic background of the European Mesolithic and the extent of population replacement during the Neolithic [1–10] is poorly understood, both due to the scarcity of human remains from that period [11–18] and the inherent methodological difficulties of ancient DNA research. However, advances in sequencing technologies are both increasing data yields and providing supporting evidence for data authenticity, such as nucleotide misincorporation patterns [19–22]. We use these methods to characterize both the mitochondrial DNA genome and generate shotgun genomic data from two exceptionally well-preserved 7,000-year-old Mesolithic individuals from La Braña-Arintero site in León (Northwestern Spain) [23]. The mitochondria of both individuals are assigned to U5b2c1, a haplotype common among the small number of other previously studied Mesolithic individuals from Northern and Central Europe. This suggests a remarkable genetic uniformity and little phylogeographic structure over a large geographic area of the pre-Neolithic populations. Using Approximate Bayesian Computation, a model of genetic continuity from Mesolithic to Neolithic populations is poorly supported. Furthermore, analyses of 1.34% and 0.53% of their nuclear genomes, containing about 50,000 and 20,000 ancestry informative SNPs, respectively, show that these two Mesolithic individuals are not related to current populations from either the Iberian Peninsula or Southern Europe. Highlights ¿ The first complete Mesolithic mtDNA genome retrieved ¿ There is a remarkable genetic uniformity in Europe during the Mesolithic period ¿ Modern Iberians are not direct descendants of the 7,000-year-old hunter-gatherers ¿ Genetic discontinuity between Mesolithic/Neolithic populations supported by simulations
KW - biology
U2 - 10.1016/j.cub.2012.06.005
DO - 10.1016/j.cub.2012.06.005
M3 - Journal article
C2 - 22748318
VL - 22
SP - 1494
EP - 1499
JO - Current Biology
JF - Current Biology
SN - 0960-9822
IS - 16
ER -
ID: 38372985