Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children

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Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children. / Mateos, Marion K.; Tulstrup, Morten; Quinn, Michael C.J.; Tuckuviene, Ruta; Marshall, Glenn M.; Gupta, Ramneek; Mayoh, Chelsea; Wolthers, Benjamin O.; Barbaro, Pasquale M.; Ruud, Ellen; Sutton, Rosemary; Huttunen, Pasi; Revesz, Tamas; Trakymiene, Sonata S.; Barbaric, Draga; Tedgård, Ulf; Giles, Jodie E.; Alvaro, Frank; Jonsson, Olafur G.; Mechinaud, Françoise; Saks, Kadri; Catchpoole, Daniel; Kotecha, Rishi S.; Dalla-Pozza, Luciano; Chenevix-Trench, Georgia; Trahair, Toby N.; Macgregor, Stuart; Schmiegelow, Kjeld.

In: Cancers, Vol. 12, No. 5, 1285, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mateos, MK, Tulstrup, M, Quinn, MCJ, Tuckuviene, R, Marshall, GM, Gupta, R, Mayoh, C, Wolthers, BO, Barbaro, PM, Ruud, E, Sutton, R, Huttunen, P, Revesz, T, Trakymiene, SS, Barbaric, D, Tedgård, U, Giles, JE, Alvaro, F, Jonsson, OG, Mechinaud, F, Saks, K, Catchpoole, D, Kotecha, RS, Dalla-Pozza, L, Chenevix-Trench, G, Trahair, TN, Macgregor, S & Schmiegelow, K 2020, 'Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children', Cancers, vol. 12, no. 5, 1285. https://doi.org/10.3390/cancers12051285

APA

Mateos, M. K., Tulstrup, M., Quinn, M. C. J., Tuckuviene, R., Marshall, G. M., Gupta, R., Mayoh, C., Wolthers, B. O., Barbaro, P. M., Ruud, E., Sutton, R., Huttunen, P., Revesz, T., Trakymiene, S. S., Barbaric, D., Tedgård, U., Giles, J. E., Alvaro, F., Jonsson, O. G., ... Schmiegelow, K. (2020). Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children. Cancers, 12(5), [1285]. https://doi.org/10.3390/cancers12051285

Vancouver

Mateos MK, Tulstrup M, Quinn MCJ, Tuckuviene R, Marshall GM, Gupta R et al. Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children. Cancers. 2020;12(5). 1285. https://doi.org/10.3390/cancers12051285

Author

Mateos, Marion K. ; Tulstrup, Morten ; Quinn, Michael C.J. ; Tuckuviene, Ruta ; Marshall, Glenn M. ; Gupta, Ramneek ; Mayoh, Chelsea ; Wolthers, Benjamin O. ; Barbaro, Pasquale M. ; Ruud, Ellen ; Sutton, Rosemary ; Huttunen, Pasi ; Revesz, Tamas ; Trakymiene, Sonata S. ; Barbaric, Draga ; Tedgård, Ulf ; Giles, Jodie E. ; Alvaro, Frank ; Jonsson, Olafur G. ; Mechinaud, Françoise ; Saks, Kadri ; Catchpoole, Daniel ; Kotecha, Rishi S. ; Dalla-Pozza, Luciano ; Chenevix-Trench, Georgia ; Trahair, Toby N. ; Macgregor, Stuart ; Schmiegelow, Kjeld. / Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children. In: Cancers. 2020 ; Vol. 12, No. 5.

Bibtex

@article{553bbc6c6b5a46c9ab077559df7eff72,
title = "Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children",
abstract = "Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied. Methods: We undertook a genome-wide association study (GWAS) meta-analysis for VTE in consecutively treated children in the Nordic/Baltic acute lymphoblastic leukemia 2008 (ALL2008) cohort and the Australian Evaluation of Risk of ALL Treatment-Related Side-Effects (ERASE) cohort. A total of 92 cases and 1481 controls of European ancestry were included. Results: No SNPs reached genome-wide significance (p < 5 × 10−8) in either cohort. Among the top 34 single-nucleotide polymorphisms (SNPs) (p < 1 × 10−6), two loci had concordant effects in both cohorts: ALOX15B (rs1804772) (MAF: 1%; p = 3.95 × 10−7) that influences arachidonic acid metabolism and thus platelet aggregation, and KALRN (rs570684) (MAF: 1%; p = 4.34 × 10−7) that has been previously associated with risk of ischemic stroke, atherosclerosis, and early-onset coronary artery disease. Conclusion: This represents the largest GWAS meta-analysis conducted to date associating SNPs to VTE in children and adolescents treated on childhood ALL protocols. Validation of these findings is needed and may then lead to patient stratification for VTE preventive interventions. As VTE hemostasis involves multiple pathways, a more powerful GWAS is needed to detect combination of variants associated with VTE.",
keywords = "Acute lymphoblastic leukemia, Child, Genome-wide association study, Single-nucleotide polymorphism, Venous thromboembolism",
author = "Mateos, {Marion K.} and Morten Tulstrup and Quinn, {Michael C.J.} and Ruta Tuckuviene and Marshall, {Glenn M.} and Ramneek Gupta and Chelsea Mayoh and Wolthers, {Benjamin O.} and Barbaro, {Pasquale M.} and Ellen Ruud and Rosemary Sutton and Pasi Huttunen and Tamas Revesz and Trakymiene, {Sonata S.} and Draga Barbaric and Ulf Tedg{\aa}rd and Giles, {Jodie E.} and Frank Alvaro and Jonsson, {Olafur G.} and Fran{\c c}oise Mechinaud and Kadri Saks and Daniel Catchpoole and Kotecha, {Rishi S.} and Luciano Dalla-Pozza and Georgia Chenevix-Trench and Trahair, {Toby N.} and Stuart Macgregor and Kjeld Schmiegelow",
year = "2020",
doi = "10.3390/cancers12051285",
language = "English",
volume = "12",
journal = "Cancers",
issn = "2072-6694",
publisher = "M D P I AG",
number = "5",

}

RIS

TY - JOUR

T1 - Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children

AU - Mateos, Marion K.

AU - Tulstrup, Morten

AU - Quinn, Michael C.J.

AU - Tuckuviene, Ruta

AU - Marshall, Glenn M.

AU - Gupta, Ramneek

AU - Mayoh, Chelsea

AU - Wolthers, Benjamin O.

AU - Barbaro, Pasquale M.

AU - Ruud, Ellen

AU - Sutton, Rosemary

AU - Huttunen, Pasi

AU - Revesz, Tamas

AU - Trakymiene, Sonata S.

AU - Barbaric, Draga

AU - Tedgård, Ulf

AU - Giles, Jodie E.

AU - Alvaro, Frank

AU - Jonsson, Olafur G.

AU - Mechinaud, Françoise

AU - Saks, Kadri

AU - Catchpoole, Daniel

AU - Kotecha, Rishi S.

AU - Dalla-Pozza, Luciano

AU - Chenevix-Trench, Georgia

AU - Trahair, Toby N.

AU - Macgregor, Stuart

AU - Schmiegelow, Kjeld

PY - 2020

Y1 - 2020

N2 - Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied. Methods: We undertook a genome-wide association study (GWAS) meta-analysis for VTE in consecutively treated children in the Nordic/Baltic acute lymphoblastic leukemia 2008 (ALL2008) cohort and the Australian Evaluation of Risk of ALL Treatment-Related Side-Effects (ERASE) cohort. A total of 92 cases and 1481 controls of European ancestry were included. Results: No SNPs reached genome-wide significance (p < 5 × 10−8) in either cohort. Among the top 34 single-nucleotide polymorphisms (SNPs) (p < 1 × 10−6), two loci had concordant effects in both cohorts: ALOX15B (rs1804772) (MAF: 1%; p = 3.95 × 10−7) that influences arachidonic acid metabolism and thus platelet aggregation, and KALRN (rs570684) (MAF: 1%; p = 4.34 × 10−7) that has been previously associated with risk of ischemic stroke, atherosclerosis, and early-onset coronary artery disease. Conclusion: This represents the largest GWAS meta-analysis conducted to date associating SNPs to VTE in children and adolescents treated on childhood ALL protocols. Validation of these findings is needed and may then lead to patient stratification for VTE preventive interventions. As VTE hemostasis involves multiple pathways, a more powerful GWAS is needed to detect combination of variants associated with VTE.

AB - Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied. Methods: We undertook a genome-wide association study (GWAS) meta-analysis for VTE in consecutively treated children in the Nordic/Baltic acute lymphoblastic leukemia 2008 (ALL2008) cohort and the Australian Evaluation of Risk of ALL Treatment-Related Side-Effects (ERASE) cohort. A total of 92 cases and 1481 controls of European ancestry were included. Results: No SNPs reached genome-wide significance (p < 5 × 10−8) in either cohort. Among the top 34 single-nucleotide polymorphisms (SNPs) (p < 1 × 10−6), two loci had concordant effects in both cohorts: ALOX15B (rs1804772) (MAF: 1%; p = 3.95 × 10−7) that influences arachidonic acid metabolism and thus platelet aggregation, and KALRN (rs570684) (MAF: 1%; p = 4.34 × 10−7) that has been previously associated with risk of ischemic stroke, atherosclerosis, and early-onset coronary artery disease. Conclusion: This represents the largest GWAS meta-analysis conducted to date associating SNPs to VTE in children and adolescents treated on childhood ALL protocols. Validation of these findings is needed and may then lead to patient stratification for VTE preventive interventions. As VTE hemostasis involves multiple pathways, a more powerful GWAS is needed to detect combination of variants associated with VTE.

KW - Acute lymphoblastic leukemia

KW - Child

KW - Genome-wide association study

KW - Single-nucleotide polymorphism

KW - Venous thromboembolism

U2 - 10.3390/cancers12051285

DO - 10.3390/cancers12051285

M3 - Journal article

C2 - 32438682

AN - SCOPUS:85085388410

VL - 12

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 5

M1 - 1285

ER -

ID: 251584022