Genetic stratification of depression in UK Biobank

Research output: Contribution to journal › Journal article › Research › peer-review

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Genetic stratification of depression in UK Biobank. / Howard, David M.; Folkersen, Lasse; Coleman, Jonathan R.; Adams, Mark J.; Glanville, Kylie; Werge, Thomas; Hagenaars, Saskia P.; Han, Buhm; Porteous, David; Campbell, Archie; Clarke, Toni-Kim; Breen, Gerome; Sullivan, Patrick F.; Wray, Naomi R.; Lewis, Cathryn M.; McIntosh, Andrew M.

In: Translational Psychiatry, Vol. 10, No. 1, 163, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Howard, DM, Folkersen, L, Coleman, JR, Adams, MJ, Glanville, K, Werge, T, Hagenaars, SP, Han, B, Porteous, D, Campbell, A, Clarke, T-K, Breen, G, Sullivan, PF, Wray, NR, Lewis, CM & McIntosh, AM 2020, 'Genetic stratification of depression in UK Biobank', Translational Psychiatry, vol. 10, no. 1, 163. https://doi.org/10.1038/s41398-020-0848-0

APA

Howard, D. M., Folkersen, L., Coleman, J. R., Adams, M. J., Glanville, K., Werge, T., Hagenaars, S. P., Han, B., Porteous, D., Campbell, A., Clarke, T-K., Breen, G., Sullivan, P. F., Wray, N. R., Lewis, C. M., & McIntosh, A. M. (2020). Genetic stratification of depression in UK Biobank. Translational Psychiatry, 10(1), [163]. https://doi.org/10.1038/s41398-020-0848-0

Vancouver

Howard DM, Folkersen L, Coleman JR, Adams MJ, Glanville K, Werge T et al. Genetic stratification of depression in UK Biobank. Translational Psychiatry. 2020;10(1). 163. https://doi.org/10.1038/s41398-020-0848-0

Author

Howard, David M. ; Folkersen, Lasse ; Coleman, Jonathan R. ; Adams, Mark J. ; Glanville, Kylie ; Werge, Thomas ; Hagenaars, Saskia P. ; Han, Buhm ; Porteous, David ; Campbell, Archie ; Clarke, Toni-Kim ; Breen, Gerome ; Sullivan, Patrick F. ; Wray, Naomi R. ; Lewis, Cathryn M. ; McIntosh, Andrew M. / Genetic stratification of depression in UK Biobank. In: Translational Psychiatry. 2020 ; Vol. 10, No. 1.

Bibtex

@article{80b4f018238546ec9245a538f200e7be,
title = "Genetic stratification of depression in UK Biobank",
abstract = "Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations were used to test for evidence of subgroups using genetic data from seven other complex traits and disorders that were genetically correlated with depression and had sufficient power (>0.6) for detection. We found no evidence for subgroups within depression for schizophrenia, bipolar disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, anorexia nervosa, inflammatory bowel disease or obesity. This suggests that for these traits, genetic correlations with depression were driven by pleiotropic genetic variants carried by everyone rather than by a specific subgroup.",
keywords = "GENOME-WIDE ASSOCIATION, MAJOR DEPRESSION, PREVALENCE, INFERENCE, INSIGHTS, LOCI",
author = "Howard, {David M.} and Lasse Folkersen and Coleman, {Jonathan R.} and Adams, {Mark J.} and Kylie Glanville and Thomas Werge and Hagenaars, {Saskia P.} and Buhm Han and David Porteous and Archie Campbell and Toni-Kim Clarke and Gerome Breen and Sullivan, {Patrick F.} and Wray, {Naomi R.} and Lewis, {Cathryn M.} and McIntosh, {Andrew M.}",
year = "2020",
doi = "10.1038/s41398-020-0848-0",
language = "English",
volume = "10",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Genetic stratification of depression in UK Biobank

AU - Howard, David M.

AU - Folkersen, Lasse

AU - Coleman, Jonathan R.

AU - Adams, Mark J.

AU - Glanville, Kylie

AU - Werge, Thomas

AU - Hagenaars, Saskia P.

AU - Han, Buhm

AU - Porteous, David

AU - Campbell, Archie

AU - Clarke, Toni-Kim

AU - Breen, Gerome

AU - Sullivan, Patrick F.

AU - Wray, Naomi R.

AU - Lewis, Cathryn M.

AU - McIntosh, Andrew M.

PY - 2020

Y1 - 2020

N2 - Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations were used to test for evidence of subgroups using genetic data from seven other complex traits and disorders that were genetically correlated with depression and had sufficient power (>0.6) for detection. We found no evidence for subgroups within depression for schizophrenia, bipolar disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, anorexia nervosa, inflammatory bowel disease or obesity. This suggests that for these traits, genetic correlations with depression were driven by pleiotropic genetic variants carried by everyone rather than by a specific subgroup.

AB - Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations were used to test for evidence of subgroups using genetic data from seven other complex traits and disorders that were genetically correlated with depression and had sufficient power (>0.6) for detection. We found no evidence for subgroups within depression for schizophrenia, bipolar disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, anorexia nervosa, inflammatory bowel disease or obesity. This suggests that for these traits, genetic correlations with depression were driven by pleiotropic genetic variants carried by everyone rather than by a specific subgroup.

KW - GENOME-WIDE ASSOCIATION

KW - MAJOR DEPRESSION

KW - PREVALENCE

KW - INFERENCE

KW - INSIGHTS

KW - LOCI

U2 - 10.1038/s41398-020-0848-0

DO - 10.1038/s41398-020-0848-0

M3 - Journal article

C2 - 32448866

VL - 10

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 1

M1 - 163

ER -

ID: 247075738