Generation and propagation of radical reactions on proteins
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Generation and propagation of radical reactions on proteins. / Hawkins, C L; Davies, Michael Jonathan.
In: B B A - Reviews on Cancer, Vol. 1504, No. 2-3, 02.04.2001, p. 196-219.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Generation and propagation of radical reactions on proteins
AU - Hawkins, C L
AU - Davies, Michael Jonathan
PY - 2001/4/2
Y1 - 2001/4/2
N2 - The oxidation of proteins by free radicals is thought to play a major role in many oxidative processes within cells and is implicated in a number of human diseases as well as ageing. This review summarises information on the formation of radicals on peptides and proteins and how radical damage may be propagated and transferred within protein structures. The emphasis of this article is primarily on the deleterious actions of radicals generated on proteins, and their mechanisms of action, rather than on enzymatic systems where radicals are deliberately formed as transient intermediates. The final section of this review examines the control of protein oxidation and how such damage might be limited by antioxidants.
AB - The oxidation of proteins by free radicals is thought to play a major role in many oxidative processes within cells and is implicated in a number of human diseases as well as ageing. This review summarises information on the formation of radicals on peptides and proteins and how radical damage may be propagated and transferred within protein structures. The emphasis of this article is primarily on the deleterious actions of radicals generated on proteins, and their mechanisms of action, rather than on enzymatic systems where radicals are deliberately formed as transient intermediates. The final section of this review examines the control of protein oxidation and how such damage might be limited by antioxidants.
KW - Alcohols
KW - Animals
KW - Antioxidants
KW - Binding Sites
KW - Electron Spin Resonance Spectroscopy
KW - Free Radicals
KW - Humans
KW - Kinetics
KW - Models, Chemical
KW - Oxidation-Reduction
KW - Peroxides
KW - Phenols
KW - Proteins
M3 - Journal article
C2 - 11245785
VL - 1504
SP - 196
EP - 219
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
SN - 0304-419X
IS - 2-3
ER -
ID: 138280278