Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain
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Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain. / Tang, Jianbo; Postnov, Dmitry D.; Kilic, Kivilcim; Erdener, Sefik Evren; Lee, Blaire; Giblin, John T.; Szabo, Thomas L.; Boas, David A.
In: Advanced Science, Vol. 7, 2001044, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain
AU - Tang, Jianbo
AU - Postnov, Dmitry D.
AU - Kilic, Kivilcim
AU - Erdener, Sefik Evren
AU - Lee, Blaire
AU - Giblin, John T.
AU - Szabo, Thomas L.
AU - Boas, David A.
PY - 2020
Y1 - 2020
N2 - A high-speed, contrast-free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first-order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring the blood flow velocity changes during whisker stimulation in awake mice. Compared to existing Power-Doppler- and Color-Doppler-based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high-frequency noise.
AB - A high-speed, contrast-free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first-order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring the blood flow velocity changes during whisker stimulation in awake mice. Compared to existing Power-Doppler- and Color-Doppler-based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high-frequency noise.
KW - brain imaging
KW - cerebral blood flow velocity
KW - field autocorrelation function
KW - functional ultrasound velocimetry
U2 - 10.1002/advs.202001044
DO - 10.1002/advs.202001044
M3 - Journal article
C2 - 32999839
AN - SCOPUS:85088446374
VL - 7
JO - Advanced Science
JF - Advanced Science
SN - 2198-3844
M1 - 2001044
ER -
ID: 246825504