Functional modeling of neural-glial interaction
Research output: Contribution to journal › Journal article › Research › peer-review
We propose a generalized mathematical model for a small neural-glial ensemble. The model incorporates subunits of the tripartite synapse that includes a presynaptic neuron, the synaptic terminal itself, a postsynaptic neuron, and a glial cell. The glial cell is assumed to be activated via two different pathways: (i) the fast increase of intercellular [K(+)] produced by the spiking activity of the postsynaptic neuron, and (ii) the slow production of a mediator triggered by the synaptic activity. Our model predicts the long-term potentiation of the postsynaptic neuron as well as various [Ca(2+)] transients in response to the activation of different pathways.
Original language | English |
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Journal | BioSystems |
Volume | 89 |
Issue number | 1-3 |
Pages (from-to) | 84-91 |
Number of pages | 8 |
ISSN | 0303-2647 |
DOIs | |
Publication status | Published - 2007 |
- Long-Term Potentiation, Models, Neurological, Neuroglia, Neurons, Potassium
Research areas
ID: 33812538