From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Research output: Contribution to journal › Journal article › Research › peer-review
A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.
Original language | English |
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Journal | Cell |
Volume | 165 |
Issue number | 6 |
Pages (from-to) | 1332-45 |
Number of pages | 14 |
ISSN | 0092-8674 |
DOIs | |
Publication status | Published - 2 Jun 2016 |
- Journal Article, Review
Research areas
ID: 166695360