Four-point impedance as a biomarker for bleeding during cochlear implantation
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Four-point impedance as a biomarker for bleeding during cochlear implantation. / Bester, Christofer; Razmovski, Tayla; Collins, Aaron; Mejia, Olivia; Foghsgaard, Søren; Mitchell-Innes, Alistair; Shaul, Chanan; Campbell, Luke; Eastwood, Hayden; O'Leary, Stephen.
In: Scientific Reports, Vol. 10, 2777, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Four-point impedance as a biomarker for bleeding during cochlear implantation
AU - Bester, Christofer
AU - Razmovski, Tayla
AU - Collins, Aaron
AU - Mejia, Olivia
AU - Foghsgaard, Søren
AU - Mitchell-Innes, Alistair
AU - Shaul, Chanan
AU - Campbell, Luke
AU - Eastwood, Hayden
AU - O'Leary, Stephen
PY - 2020
Y1 - 2020
N2 - Cochlear implantation has successfully restored the perception of hearing for nearly 200 thousand profoundly deaf adults and children. More recently, implant candidature has expanded to include those with considerable natural hearing which, when preserved, provides an improved hearing experience in noisy environments. But more than half of these patients lose this natural hearing soon after implantation. To reduce this burden, biosensing technologies are emerging that provide feedback on the quality of surgery. Here we report clinical findings on a new intra-operative measurement of electrical impedance (4-point impedance) which, when elevated, is associated with high rates of post-operative hearing loss and vestibular dysfunction. In vivo and in vitro data presented suggest that elevated 4-point impedance is likely due to the presence of blood within the cochlea rather than its geometry. Four-point impedance is a new marker for the detection of cochlear injury causing bleeding, that may be incorporated into intraoperative monitoring protocols during CI surgery.
AB - Cochlear implantation has successfully restored the perception of hearing for nearly 200 thousand profoundly deaf adults and children. More recently, implant candidature has expanded to include those with considerable natural hearing which, when preserved, provides an improved hearing experience in noisy environments. But more than half of these patients lose this natural hearing soon after implantation. To reduce this burden, biosensing technologies are emerging that provide feedback on the quality of surgery. Here we report clinical findings on a new intra-operative measurement of electrical impedance (4-point impedance) which, when elevated, is associated with high rates of post-operative hearing loss and vestibular dysfunction. In vivo and in vitro data presented suggest that elevated 4-point impedance is likely due to the presence of blood within the cochlea rather than its geometry. Four-point impedance is a new marker for the detection of cochlear injury causing bleeding, that may be incorporated into intraoperative monitoring protocols during CI surgery.
KW - Aged
KW - Biomarkers/blood
KW - Biosensing Techniques/methods
KW - Cochlea/pathology
KW - Cochlear Implantation/adverse effects
KW - Cochlear Implants/adverse effects
KW - Electric Impedance/therapeutic use
KW - Female
KW - Hearing Loss/blood
KW - Hearing Tests
KW - Hemorrhage/blood
KW - Humans
KW - Male
KW - Postoperative Complications/blood
KW - Translational Medical Research
U2 - 10.1038/s41598-019-56253-w
DO - 10.1038/s41598-019-56253-w
M3 - Journal article
C2 - 32066743
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 2777
ER -
ID: 257038925