Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia
Research output: Contribution to journal › Journal article › Research › peer-review
Infants with acute lymphoblastic leukaemia (ALL) have a high frequency of central nervous system (CNS) involvement. Flow cytometric analysis of cerebrospinal fluid (CSF) was recently demonstrated to be a sensitive method for detecting CNS involvement in childhood ALL. In the present study, CSF from 14 infants was collected at routine lumbar punctures and analysed by multicolour flow cytometry. At initial diagnosis, leukaemic blasts were detected in CSF by flow cytometry in 11 patients (78·6%) compared to seven patients (50%) by cytospin. Larger studies are needed to determine if CSF flow cytometry has prognostic value in infant ALL.
Original language | English |
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Journal | British Journal of Haematology |
Volume | 195 |
Issue number | 1 |
Pages (from-to) | 119-122 |
ISSN | 0007-1048 |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Publisher Copyright:
© 2021 British Society for Haematology and John Wiley & Sons Ltd
- ALL, central nervous system, cerebrospinal fluid, childhood, flow cytometry, metastasis
Research areas
ID: 276854889