Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation
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Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation. / Zakiudin, Dinastry Pramadita; Thyssen, Jacob P.; Zachariae, Claus; Videm, Vibeke; Øien, Torbjørn; Simpson, Melanie Rae.
In: Acta Dermato-Venereologica, Vol. 104, adv24360, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation
AU - Zakiudin, Dinastry Pramadita
AU - Thyssen, Jacob P.
AU - Zachariae, Claus
AU - Videm, Vibeke
AU - Øien, Torbjørn
AU - Simpson, Melanie Rae
PY - 2024
Y1 - 2024
N2 - The World Allergy Organization recommends probiotics in the prevention of atopic dermatitis in high-risk populations. Mutations in the filaggrin gene (FLG) result in an increased risk of atopic dermatitis through disruption of the skin keratin layer. This exploratory study investigated whether the preventive effect of maternal probiotics was evident in children with and without FLG mutations. DNA was collected from children (n = 228) from the Probiotic in the Prevention of Allergy among Children in Trondheim (ProPACT) study. Samples were analysed for 3 common FLG mutations (R501X, R2447X, and 2282del4). Overall, 7% of children had heterozygous FLG mutations; each child had only one of the 3 mutations. Mutation status had no association with atopic dermatitis (RR = 1.1; 95% CI 0.5 to 2.3). The risk ratio (RR) for having atopic dermatitis following maternal probiotics was 0.6 (95% CI 0.4 to 0.9) and RR was similar if the child expressed an FLG mutation (RR = 0.6; 95% CI 0.1 to 4.1) or wildtype FLG (RR = 0.6; 95% CI 0.4 to 0.9). The preventive effect of probiotics for atopic dermatitis was also evident in children without FLG mutation. Larger confirmatory studies are needed.
AB - The World Allergy Organization recommends probiotics in the prevention of atopic dermatitis in high-risk populations. Mutations in the filaggrin gene (FLG) result in an increased risk of atopic dermatitis through disruption of the skin keratin layer. This exploratory study investigated whether the preventive effect of maternal probiotics was evident in children with and without FLG mutations. DNA was collected from children (n = 228) from the Probiotic in the Prevention of Allergy among Children in Trondheim (ProPACT) study. Samples were analysed for 3 common FLG mutations (R501X, R2447X, and 2282del4). Overall, 7% of children had heterozygous FLG mutations; each child had only one of the 3 mutations. Mutation status had no association with atopic dermatitis (RR = 1.1; 95% CI 0.5 to 2.3). The risk ratio (RR) for having atopic dermatitis following maternal probiotics was 0.6 (95% CI 0.4 to 0.9) and RR was similar if the child expressed an FLG mutation (RR = 0.6; 95% CI 0.1 to 4.1) or wildtype FLG (RR = 0.6; 95% CI 0.4 to 0.9). The preventive effect of probiotics for atopic dermatitis was also evident in children without FLG mutation. Larger confirmatory studies are needed.
U2 - 10.2340/actadv.v104.24360
DO - 10.2340/actadv.v104.24360
M3 - Journal article
C2 - 38655655
AN - SCOPUS:85191401970
VL - 104
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
M1 - adv24360
ER -
ID: 391210887