Fibrin adhesives and cyanoacrylates are used in surgical specialties due to their ability of fixating tissue. The fibrin-based adhesives mimic the blood's own coagulation cascade, while the cyanoacrylate-based products function like commercially available superglue. The use of adhesives varies from skin lacerations to highly complicated surgical procedures, and adhesives provide an alternative or combined method of fixation to traditional fixation as suture. We present results from various clinical studies to investigate the use of fibrin-based and cyanoacrylate adhesives.