Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells
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Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells. / De Zio, D.; Ferraro, E.; D'Amelio, M.; Simoni, V.; Bordi, M.; Soroldoni, D.; Berghella, L.; Meyer, B. I.; Cecconi, F.
In: Cellular and Molecular Life Sciences, Vol. 65, No. 11, 06.2008, p. 1780-1790.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Faf1 is expressed during neurodevelopment and is involved in Apaf1-dependent caspase-3 activation in proneural cells
AU - De Zio, D.
AU - Ferraro, E.
AU - D'Amelio, M.
AU - Simoni, V.
AU - Bordi, M.
AU - Soroldoni, D.
AU - Berghella, L.
AU - Meyer, B. I.
AU - Cecconi, F.
PY - 2008/6
Y1 - 2008/6
N2 - Fas-associated factor 1 (Faf1) has been described as a Fas-binding pro-apoptotic protein and as a component of the death-inducing signaling complex (DISC) in Fas-mediated apoptosis. Faf1 is able to potentiate Fas-induced apoptosis in several cell lines, although its specific functions are still not clear. Here we show that Faf1 is highly expressed in several areas of the developing telencephalon. Its expression pattern appears to be dynamic at different embryonic stages and to be progressively confined within limited territories. To decipher the specific role of Faf1 in developing brain, we used cDNA over-expression and mRNA down-regulation experiments to modulate Faf1 expression in telencephalic neural precursor cells, and we showed that in neural cell death Faf1 acts as a Fas-independent apoptotic enhancer. Moreover, we found that Faf1 protein level is down-regulated during apoptosis in a caspase- and Apaf1-dependent manner.
AB - Fas-associated factor 1 (Faf1) has been described as a Fas-binding pro-apoptotic protein and as a component of the death-inducing signaling complex (DISC) in Fas-mediated apoptosis. Faf1 is able to potentiate Fas-induced apoptosis in several cell lines, although its specific functions are still not clear. Here we show that Faf1 is highly expressed in several areas of the developing telencephalon. Its expression pattern appears to be dynamic at different embryonic stages and to be progressively confined within limited territories. To decipher the specific role of Faf1 in developing brain, we used cDNA over-expression and mRNA down-regulation experiments to modulate Faf1 expression in telencephalic neural precursor cells, and we showed that in neural cell death Faf1 acts as a Fas-independent apoptotic enhancer. Moreover, we found that Faf1 protein level is down-regulated during apoptosis in a caspase- and Apaf1-dependent manner.
KW - Apaf1
KW - Apoptosis
KW - Caspase(s)
KW - Cell death
KW - Neurodevelopment
UR - http://www.scopus.com/inward/record.url?scp=44749090748&partnerID=8YFLogxK
U2 - 10.1007/s00018-008-8075-5
DO - 10.1007/s00018-008-8075-5
M3 - Journal article
C2 - 18480964
AN - SCOPUS:44749090748
VL - 65
SP - 1780
EP - 1790
JO - Critical Sociology
JF - Critical Sociology
SN - 0896-9205
IS - 11
ER -
ID: 338889403