Extreme Reticulocytosis after Splenectomy in a Patient with Hemoglobin Mizuho
Research output: Contribution to journal › Journal article › Research › peer-review
Background: Patients with Hb Mizuho may be splenectomized at a young age to decrease their need for blood transfusions. Observations: Transfusion-dependency decreased dramatically in a 4-year-old white boy with Hb Mizuho after splenectomy. Surprisingly, he developed reticulocytosis (>1000×109/L) with a peak reticulocyte percentage of 49%, and erythrocyte abnormalities, including Heinz bodies, Howell-Jolly bodies, and basophilic stippling. Manual reticulocyte counting and flow cytometric measurement with anti-CD71 antibodies supported a truly elevated reticulocyte count. Conclusions: We propose possible explanations for the extreme reticulocytosis that arose postsplenectomy and compare the reticulocyte count in the present case with previously published cases.
Original language | English |
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Journal | Journal of Pediatric Hematology/Oncology |
Volume | 46 |
Issue number | 1 |
Pages (from-to) | E111-E114 |
Number of pages | 4 |
ISSN | 1077-4114 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
- Hb Mizuho, hemoglobinopathy, reticulocytosis, splenectomy
Research areas
ID: 398644067