Extreme Reticulocytosis after Splenectomy in a Patient with Hemoglobin Mizuho
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Extreme Reticulocytosis after Splenectomy in a Patient with Hemoglobin Mizuho. / Narvestad-Bøttger, Helene; Winther-Larsen, Anne; Haugbølle Bjerre, Jens; Dziegiel, Morten Hanefeld; Hansen, Anne Todsen; Hasle, Henrik.
In: Journal of Pediatric Hematology/Oncology, Vol. 46, No. 1, 2024, p. E111-E114.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Extreme Reticulocytosis after Splenectomy in a Patient with Hemoglobin Mizuho
AU - Narvestad-Bøttger, Helene
AU - Winther-Larsen, Anne
AU - Haugbølle Bjerre, Jens
AU - Dziegiel, Morten Hanefeld
AU - Hansen, Anne Todsen
AU - Hasle, Henrik
N1 - Publisher Copyright: © 2024 Lippincott Williams and Wilkins. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Background: Patients with Hb Mizuho may be splenectomized at a young age to decrease their need for blood transfusions. Observations: Transfusion-dependency decreased dramatically in a 4-year-old white boy with Hb Mizuho after splenectomy. Surprisingly, he developed reticulocytosis (>1000×109/L) with a peak reticulocyte percentage of 49%, and erythrocyte abnormalities, including Heinz bodies, Howell-Jolly bodies, and basophilic stippling. Manual reticulocyte counting and flow cytometric measurement with anti-CD71 antibodies supported a truly elevated reticulocyte count. Conclusions: We propose possible explanations for the extreme reticulocytosis that arose postsplenectomy and compare the reticulocyte count in the present case with previously published cases.
AB - Background: Patients with Hb Mizuho may be splenectomized at a young age to decrease their need for blood transfusions. Observations: Transfusion-dependency decreased dramatically in a 4-year-old white boy with Hb Mizuho after splenectomy. Surprisingly, he developed reticulocytosis (>1000×109/L) with a peak reticulocyte percentage of 49%, and erythrocyte abnormalities, including Heinz bodies, Howell-Jolly bodies, and basophilic stippling. Manual reticulocyte counting and flow cytometric measurement with anti-CD71 antibodies supported a truly elevated reticulocyte count. Conclusions: We propose possible explanations for the extreme reticulocytosis that arose postsplenectomy and compare the reticulocyte count in the present case with previously published cases.
KW - Hb Mizuho
KW - hemoglobinopathy
KW - reticulocytosis
KW - splenectomy
U2 - 10.1097/MPH.0000000000002790
DO - 10.1097/MPH.0000000000002790
M3 - Journal article
C2 - 38011049
AN - SCOPUS:85181586201
VL - 46
SP - E111-E114
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 1
ER -
ID: 398644067