Exhaled nitric oxide in premature and mature infants during the first months of life: Exhaled Nitric Oxide in neonates – a review
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Exhaled nitric oxide in premature and mature infants during the first months of life : Exhaled Nitric Oxide in neonates – a review. / Goth, Fanny E.M.; Schmidt, Birgitte J.; Agertoft, Lone; Jørgensen, Inger Merete.
In: Nitric Oxide - Biology and Chemistry, Vol. 113-114, 2021, p. 7-12.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Exhaled nitric oxide in premature and mature infants during the first months of life
T2 - Exhaled Nitric Oxide in neonates – a review
AU - Goth, Fanny E.M.
AU - Schmidt, Birgitte J.
AU - Agertoft, Lone
AU - Jørgensen, Inger Merete
N1 - Publisher Copyright: © 2021 Elsevier Inc.
PY - 2021
Y1 - 2021
N2 - Aim: In this review, we aim to describe how exhaled Nitric Oxide(NO) changes during the first months of life in premature and mature infants. Method: Review of the literature up to August 2020, on online, tidal breathing NO measurements in unsedated infants. The association between Fractional exhaled NO(FeNO) values, postnatal age, and prematurity was analysed using linear mixed modeling and Spearman's rank correlation. Results: Median FeNO during the first months of life was 5.9 and 8.5 ppb in premature and mature infants, respectively. The linear mixed model analysis showed a significant effect of postnatal age on FeNO (p = 0.007). Conclusion: Our study suggests that FeNO is higher in mature infants than premature infants, and FeNO increased with postnatal age at approximately the same pace in both groups.
AB - Aim: In this review, we aim to describe how exhaled Nitric Oxide(NO) changes during the first months of life in premature and mature infants. Method: Review of the literature up to August 2020, on online, tidal breathing NO measurements in unsedated infants. The association between Fractional exhaled NO(FeNO) values, postnatal age, and prematurity was analysed using linear mixed modeling and Spearman's rank correlation. Results: Median FeNO during the first months of life was 5.9 and 8.5 ppb in premature and mature infants, respectively. The linear mixed model analysis showed a significant effect of postnatal age on FeNO (p = 0.007). Conclusion: Our study suggests that FeNO is higher in mature infants than premature infants, and FeNO increased with postnatal age at approximately the same pace in both groups.
KW - Exhaled nitric oxide
KW - Lung development
KW - Neonatal
KW - Premature
U2 - 10.1016/j.niox.2021.04.005
DO - 10.1016/j.niox.2021.04.005
M3 - Review
C2 - 33866006
AN - SCOPUS:85105832750
VL - 113-114
SP - 7
EP - 12
JO - Nitric Oxide: Biology and Chemistry
JF - Nitric Oxide: Biology and Chemistry
SN - 1089-8603
ER -
ID: 269607442