Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success?
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Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success? / Ravndal, Maren; Idorn, Lars; Nielsen, Anne Kathrine Møller; Kelly, Benjamin; Nielsen, Kim Gjerum; Nielsen, Dorte Guldbrand; Hjortdal, Vibeke.
In: International Journal of Cardiology, Vol. 387, 131137, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success?
AU - Ravndal, Maren
AU - Idorn, Lars
AU - Nielsen, Anne Kathrine Møller
AU - Kelly, Benjamin
AU - Nielsen, Kim Gjerum
AU - Nielsen, Dorte Guldbrand
AU - Hjortdal, Vibeke
N1 - Funding Information: This work was supported by a common grant from The Novo Nordisk Foundation ( #NFF17SA0030576 ). Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - Background: Most Fontan patients have impaired exercise capacity, and a further decline in exercise capacity over time seems inevitable. However, few longitudinal studies exist, and there is a lack of data from newer eras. We aimed to describe the natural evolution of exercise capacity over a 10-year period in a contemporary, population-based cohort of Danish Fontan patients. Methods: The study was a nationwide, prospective study. A cardiopulmonary exercise test (CPET) was used to assess the exercise capacity. All Danish Fontan patients who participated in a national study in 2011 (CPET1), were invited to a follow-up visit in 2021 (CPET2). All patients who completed CPET1 and CPET2 with a respiratory exchange ratio over 1.0 were included. The main outcome was percent predicted VO2peak (%pred VO2peak). At the time of CPET2, patients filled out a questionnaire including questions regarding physical activity. Results: Seventy-seven patients completed both CPET1 and CPET2, and seventy patients completed the questionnaire. The time interval between the two CPETs was 10.4 ± 0.9 years. The median age was 15 years at CPET1 and 26 years at CPET2. The exercise capacity remained stable with a mean %pred VO2peak of 53.8 ± 11.3 at CPET1 and 55.6 ± 10.9 in CPET2 (p = 0.314). Higher levels of vigorous physical activity were associated with higher %pred VO2peak in CPET2 in a multivariate regression model. Conclusion: The %pred VO2peak remained stable over a ten-year period in this population-based Fontan cohort. Higher levels of self-reported vigorous physical activity were associated with higher %pred VO2peak in the most recent CPET.
AB - Background: Most Fontan patients have impaired exercise capacity, and a further decline in exercise capacity over time seems inevitable. However, few longitudinal studies exist, and there is a lack of data from newer eras. We aimed to describe the natural evolution of exercise capacity over a 10-year period in a contemporary, population-based cohort of Danish Fontan patients. Methods: The study was a nationwide, prospective study. A cardiopulmonary exercise test (CPET) was used to assess the exercise capacity. All Danish Fontan patients who participated in a national study in 2011 (CPET1), were invited to a follow-up visit in 2021 (CPET2). All patients who completed CPET1 and CPET2 with a respiratory exchange ratio over 1.0 were included. The main outcome was percent predicted VO2peak (%pred VO2peak). At the time of CPET2, patients filled out a questionnaire including questions regarding physical activity. Results: Seventy-seven patients completed both CPET1 and CPET2, and seventy patients completed the questionnaire. The time interval between the two CPETs was 10.4 ± 0.9 years. The median age was 15 years at CPET1 and 26 years at CPET2. The exercise capacity remained stable with a mean %pred VO2peak of 53.8 ± 11.3 at CPET1 and 55.6 ± 10.9 in CPET2 (p = 0.314). Higher levels of vigorous physical activity were associated with higher %pred VO2peak in CPET2 in a multivariate regression model. Conclusion: The %pred VO2peak remained stable over a ten-year period in this population-based Fontan cohort. Higher levels of self-reported vigorous physical activity were associated with higher %pred VO2peak in the most recent CPET.
KW - Cardiopulmonary exercise test
KW - Congenital heart disease
KW - Fontan circulation
KW - Physical activity
U2 - 10.1016/j.ijcard.2023.131137
DO - 10.1016/j.ijcard.2023.131137
M3 - Journal article
C2 - 37355241
AN - SCOPUS:85163539575
VL - 387
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
M1 - 131137
ER -
ID: 388831156