Exercise as a mean to control low-grade systemic inflammation
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Exercise as a mean to control low-grade systemic inflammation. / Mathur, Neha; Pedersen, Bente Klarlund.
In: Mediators of Inflammation, Vol. 2008, 01.01.2008, p. 109502.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Exercise as a mean to control low-grade systemic inflammation
AU - Mathur, Neha
AU - Pedersen, Bente Klarlund
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide. It has now become clear that low-grade chronic inflammation is a key player in the pathogenesis of most CNCDs. Given that regular exercise offers protection against all causes of mortality, primarily by protection against atherosclerosis and insulin resistance, we suggest that exercise may exert some of its beneficial health effects by inducing anti-inflammatory actions. Recently, IL-6 was introduced as the first myokine, defined as a cytokine, which is produced and released by contracting skeletal muscle fibres, exerting its effects in other organs of the body. We suggest that skeletal muscle is an endocrine organ and that myokines may be involved in mediating the beneficial effects against CNCDs associated with low-grade inflammation.
AB - Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide. It has now become clear that low-grade chronic inflammation is a key player in the pathogenesis of most CNCDs. Given that regular exercise offers protection against all causes of mortality, primarily by protection against atherosclerosis and insulin resistance, we suggest that exercise may exert some of its beneficial health effects by inducing anti-inflammatory actions. Recently, IL-6 was introduced as the first myokine, defined as a cytokine, which is produced and released by contracting skeletal muscle fibres, exerting its effects in other organs of the body. We suggest that skeletal muscle is an endocrine organ and that myokines may be involved in mediating the beneficial effects against CNCDs associated with low-grade inflammation.
KW - Exercise
KW - Humans
KW - Inflammation
KW - Interleukin-6
KW - Muscle, Skeletal
U2 - 10.1155/2008/109502
DO - 10.1155/2008/109502
M3 - Journal article
C2 - 19148295
VL - 2008
SP - 109502
JO - Mediators of Inflammation
JF - Mediators of Inflammation
SN - 0962-9351
ER -
ID: 35292762