Exercise and fat accumulation in the human liver
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Exercise and fat accumulation in the human liver. / Magkos, Faidon.
In: Current Opinion in Lipidology, Vol. 21, No. 6, 2010, p. 507-517.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Exercise and fat accumulation in the human liver
AU - Magkos, Faidon
N1 - (Ekstern)
PY - 2010
Y1 - 2010
N2 - Purpose of review: Fat accumulation in the liver is strongly associated with metabolic dysfunction. Regular exercise improves many cardiometabolic risks factors; however, its effect on intrahepatic triglyceride (IHTG) content remains elusive. This article summarizes available data regarding the effects of exercise on IHTG.Recent findings: Several but not all observational studies report negative associations of habitual physical activity and cardiorespiratory fitness with IHTG and the prevalence of fatty liver. Aerobic exercise training in combination with hypocaloric diet reduces IHTG by a considerable amount (20-60%), even when weight loss is mild (<5%); hence weight loss per se may not be a critical factor. Longitudinal studies involving exercise training without dietary restriction and no weight loss demonstrate that increased cardiorespiratory fitness and reduced intra-abdominal adiposity are not invariably associated with liver fat depletion, whereas relatively large exercise-induced reductions in IHTG content (20-40%) can occur even in the absence of changes in body weight, body composition, or visceral adipose tissue. Although the majority of studies have examined aerobic training, resistance exercise has also been shown to be inversely associated with the prevalence of fatty liver in humans and effectively reduces IHTG content in animals.Summary: Exercise does hold promise as an effective treatment for hepatic steatosis; this field of research is still in its infancy, and there is much more to be learned.
AB - Purpose of review: Fat accumulation in the liver is strongly associated with metabolic dysfunction. Regular exercise improves many cardiometabolic risks factors; however, its effect on intrahepatic triglyceride (IHTG) content remains elusive. This article summarizes available data regarding the effects of exercise on IHTG.Recent findings: Several but not all observational studies report negative associations of habitual physical activity and cardiorespiratory fitness with IHTG and the prevalence of fatty liver. Aerobic exercise training in combination with hypocaloric diet reduces IHTG by a considerable amount (20-60%), even when weight loss is mild (<5%); hence weight loss per se may not be a critical factor. Longitudinal studies involving exercise training without dietary restriction and no weight loss demonstrate that increased cardiorespiratory fitness and reduced intra-abdominal adiposity are not invariably associated with liver fat depletion, whereas relatively large exercise-induced reductions in IHTG content (20-40%) can occur even in the absence of changes in body weight, body composition, or visceral adipose tissue. Although the majority of studies have examined aerobic training, resistance exercise has also been shown to be inversely associated with the prevalence of fatty liver in humans and effectively reduces IHTG content in animals.Summary: Exercise does hold promise as an effective treatment for hepatic steatosis; this field of research is still in its infancy, and there is much more to be learned.
KW - Animals
KW - Body Fat Distribution
KW - Energy Metabolism/physiology
KW - Exercise/physiology
KW - Exercise Therapy
KW - Fatty Liver/metabolism
KW - Female
KW - Humans
KW - Intra-Abdominal Fat/metabolism
KW - Lipid Metabolism/physiology
KW - Liver/metabolism
KW - Longitudinal Studies
KW - Male
KW - Obesity/metabolism
KW - Physical Fitness/physiology
KW - Rodentia
KW - Triglycerides/metabolism
KW - Weight Loss
U2 - 10.1097/MOL.0b013e32833ea912
DO - 10.1097/MOL.0b013e32833ea912
M3 - Review
C2 - 21206340
VL - 21
SP - 507
EP - 517
JO - Current Opinion in Lipidology
JF - Current Opinion in Lipidology
SN - 0957-9672
IS - 6
ER -
ID: 290519939