Evolving hidden Markov models for protein secondary structure prediction
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Evolving hidden Markov models for protein secondary structure prediction. / Won, Kyoung Jae; Hamelryck, Thomas; Prügel-Bennett, Adam; Krogh, Anders.
The 2005 IEEE Congress on Evolutionary Computation, IEEE CEC 2005: Proceedings. Vol. 3 IEEE, 2005. p. 33-40.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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TY - GEN
T1 - Evolving hidden Markov models for protein secondary structure prediction
AU - Won, Kyoung Jae
AU - Hamelryck, Thomas
AU - Prügel-Bennett, Adam
AU - Krogh, Anders
PY - 2005
Y1 - 2005
N2 - New results are presented for the prediction of secondary structure information for protein sequences using Hidden Markov Models (HMMs) evolved using a Genetic Algorithm (GA). We achieved a Q 3 measure of 75% using one of the most stringent data set ever used for protein secondary structure prediction. Our results beat the best hand-designed HMM currently available and are comparable to the best known techniques for this problem. A hybrid GA incorporating the Baum-Welch algorithm was used. The topology of the HMM was restricted to biologically meaningful building blocks. Mutation and crossover operators were designed to explore this space of topologies.
AB - New results are presented for the prediction of secondary structure information for protein sequences using Hidden Markov Models (HMMs) evolved using a Genetic Algorithm (GA). We achieved a Q 3 measure of 75% using one of the most stringent data set ever used for protein secondary structure prediction. Our results beat the best hand-designed HMM currently available and are comparable to the best known techniques for this problem. A hybrid GA incorporating the Baum-Welch algorithm was used. The topology of the HMM was restricted to biologically meaningful building blocks. Mutation and crossover operators were designed to explore this space of topologies.
U2 - 10.1109/CEC.2005.1554664
DO - 10.1109/CEC.2005.1554664
M3 - Article in proceedings
AN - SCOPUS:27144535913
SN - 0-7803-9363-5
VL - 3
SP - 33
EP - 40
BT - The 2005 IEEE Congress on Evolutionary Computation, IEEE CEC 2005
PB - IEEE
T2 - 2005 IEEE Congress on Evolutionary Computation, IEEE CEC 2005
Y2 - 2 September 2005 through 5 September 2005
ER -
ID: 199873169