Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children
Research output: Contribution to journal › Journal article › Research › peer-review
We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children had received three doses of vaccine. PT IgA responders did not have significantly longer coughing episodes than PT IgA non-responders. Since an IgA antibody response occurs in only approximately 50% of infected children, the actual infection rate in our cohort is estimated to approximately 10%. The apparent high Bordetella pertussis infection rate in Danish infants suggests that the monocomponent PT toxoid vaccine used in Denmark has limited efficacy against B. pertussis infection. A prospective immunization study comparing a multi-component vaccine with the present monocomponent PT toxoid vaccine should be undertaken.
Original language | English |
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Journal | European Journal of Pediatrics |
Volume | 169 |
Issue number | 9 |
Pages (from-to) | 1119-22 |
ISSN | 0340-6199 |
DOIs | |
Publication status | Published - 2010 |
ID: 34098401