Evaluation of topical morphine for treatment of oral mucositis in cancer patients
Research output: Contribution to journal › Journal article › Research › peer-review
Introduction: Oral mucositis is a painful side effect to chemotherapy. Orally applied opioids may offer analgesia with fewer side effects than systemic opioids.
Methods: A randomized trial comparing the analgesic effect of a morphine oromucosal solution (OM) to placebo and a positive control group receiving intravenous (IV) morphine as an add-on treatment to morphine patient-controlled analgesia (PCA) in a mixed population of paediatric and adult haematology patients. All patients in the study were equipped with a morphine PCA pump and the participating patients were instructed to use this pump as an escape. Primary outcome was morphine consumption (mg/kg/hour) on the PCA pump. Secondary outcomes included pain intensity difference at rest and when performing oral hygiene, time to first PCA bolus, nutrition intake and adverse events.
Findings: A total of 60 patients (38 children
Conclusion: The findings indicate that the analgesic effect of peripherally applied morphine is not significantly different from placebo, and parenteral opioids should continue to be the standard of care.
Original language | English |
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Journal | British Journal of Pain |
Volume | 15 |
Issue number | 4 |
Pages (from-to) | 409–417 |
ISSN | 2049-4637 |
DOIs | |
Publication status | Published - 2021 |
- Oral mucositis, morphine, peripheral, cancer, children, OROPHARYNGEAL MUCOSITIS, CONTROLLED ANALGESIA, PAIN, CHILDREN, MANAGEMENT, CHEMOTHERAPY, ADOLESCENTS
Research areas
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611291/pdf/10.1177_2049463720975061.pdf
Final published version
ID: 255735582