Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer. / Calmels, Lucie; Sibolt, Patrik; Åström, Lina M.; Serup-Hansen, Eva; Lindberg, Henriette; Fromm, Anna Lene; Persson, Gitte; Sjöström, David; Geertsen, Poul; Behrens, Claus P.

In: Technical Innovations and Patient Support in Radiation Oncology, Vol. 22, 2022, p. 30-36.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Calmels, L, Sibolt, P, Åström, LM, Serup-Hansen, E, Lindberg, H, Fromm, AL, Persson, G, Sjöström, D, Geertsen, P & Behrens, CP 2022, 'Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer', Technical Innovations and Patient Support in Radiation Oncology, vol. 22, pp. 30-36. https://doi.org/10.1016/j.tipsro.2022.04.001

APA

Calmels, L., Sibolt, P., Åström, L. M., Serup-Hansen, E., Lindberg, H., Fromm, A. L., Persson, G., Sjöström, D., Geertsen, P., & Behrens, C. P. (2022). Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer. Technical Innovations and Patient Support in Radiation Oncology, 22, 30-36. https://doi.org/10.1016/j.tipsro.2022.04.001

Vancouver

Calmels L, Sibolt P, Åström LM, Serup-Hansen E, Lindberg H, Fromm AL et al. Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer. Technical Innovations and Patient Support in Radiation Oncology. 2022;22:30-36. https://doi.org/10.1016/j.tipsro.2022.04.001

Author

Calmels, Lucie ; Sibolt, Patrik ; Åström, Lina M. ; Serup-Hansen, Eva ; Lindberg, Henriette ; Fromm, Anna Lene ; Persson, Gitte ; Sjöström, David ; Geertsen, Poul ; Behrens, Claus P. / Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer. In: Technical Innovations and Patient Support in Radiation Oncology. 2022 ; Vol. 22. pp. 30-36.

Bibtex

@article{6b2fcf3deb43464490552be8f543e14f,

title = "Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer",

abstract = "Background and purpose: The Ethos system has enabled online adaptive radiotherapy (oART) by implementing an automated treatment planning system (aTPS) for both intensity-modulated radiotherapy (IMRT) and volumetric modulated arc radiotherapy (VMAT) plan creation. The purpose of this study is to evaluate the quality of aTPS plans in the pelvic region. Material and Methods: Sixty patients with anal (n = 20), rectal (n = 20) or prostate (n = 20) cancer were retrospectively re-planned with the aTPS. Three IMRT (7-, 9- and 12-field) and two VMAT (2 and 3 arc) automatically generated plans (APs) were created per patient. The duration of the automated plan generation was registered. The best IMRT-AP and VMAT-AP for each patient were selected based on target coverage and dose to organs at risk (OARs). The AP quality was analyzed and compared to corresponding clinically accepted and manually generated VMAT plans (MPs) using several clinically relevant dose metrics. Calculation-based pre-treatment plan quality assurance (QA) was performed for all plans. Results: The median total duration to generate the five APs with the aTPS was 55 min, 39 min and 35 min for anal, prostate and rectal plans, respectively. The target coverage and the OAR sparing were equivalent for IMRT-APs and VMAT-MPs, while VMAT-Aps. demonstrated lower target dose homogeneity and higher dose to some OARs. Both conformity and homogeneity index were equivalent (rectal) or better (anal and prostate) for IMRT-APs compared to VMAT-MPs. All plans passed the patient-specific QA tolerance limit. Conclusions: The aTPS generates plans comparable to MPs within a short time-frame which is highly relevant for oART treatments.",

keywords = "Automated treatment planning, Intelligent optimization engine, Online adaptive radiotherapy, Pelvic cancer, Plan quality, Template-based Ethos TPS",

author = "Lucie Calmels and Patrik Sibolt and {\AA}str{\"o}m, {Lina M.} and Eva Serup-Hansen and Henriette Lindberg and Fromm, {Anna Lene} and Gitte Persson and David Sj{\"o}str{\"o}m and Poul Geertsen and Behrens, {Claus P.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

doi = "10.1016/j.tipsro.2022.04.001",

language = "English",

volume = "22",

pages = "30--36",

journal = "Technical Innovations and Patient Support in Radiation Oncology",

issn = "2405-6324",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Evaluation of an automated template-based treatment planning system for radiotherapy of anal, rectal and prostate cancer

AU - Calmels, Lucie

AU - Sibolt, Patrik

AU - Åström, Lina M.

AU - Serup-Hansen, Eva

AU - Lindberg, Henriette

AU - Fromm, Anna Lene

AU - Persson, Gitte

AU - Sjöström, David

AU - Geertsen, Poul

AU - Behrens, Claus P.

PY - 2022

Y1 - 2022

N2 - Background and purpose: The Ethos system has enabled online adaptive radiotherapy (oART) by implementing an automated treatment planning system (aTPS) for both intensity-modulated radiotherapy (IMRT) and volumetric modulated arc radiotherapy (VMAT) plan creation. The purpose of this study is to evaluate the quality of aTPS plans in the pelvic region. Material and Methods: Sixty patients with anal (n = 20), rectal (n = 20) or prostate (n = 20) cancer were retrospectively re-planned with the aTPS. Three IMRT (7-, 9- and 12-field) and two VMAT (2 and 3 arc) automatically generated plans (APs) were created per patient. The duration of the automated plan generation was registered. The best IMRT-AP and VMAT-AP for each patient were selected based on target coverage and dose to organs at risk (OARs). The AP quality was analyzed and compared to corresponding clinically accepted and manually generated VMAT plans (MPs) using several clinically relevant dose metrics. Calculation-based pre-treatment plan quality assurance (QA) was performed for all plans. Results: The median total duration to generate the five APs with the aTPS was 55 min, 39 min and 35 min for anal, prostate and rectal plans, respectively. The target coverage and the OAR sparing were equivalent for IMRT-APs and VMAT-MPs, while VMAT-Aps. demonstrated lower target dose homogeneity and higher dose to some OARs. Both conformity and homogeneity index were equivalent (rectal) or better (anal and prostate) for IMRT-APs compared to VMAT-MPs. All plans passed the patient-specific QA tolerance limit. Conclusions: The aTPS generates plans comparable to MPs within a short time-frame which is highly relevant for oART treatments.

AB - Background and purpose: The Ethos system has enabled online adaptive radiotherapy (oART) by implementing an automated treatment planning system (aTPS) for both intensity-modulated radiotherapy (IMRT) and volumetric modulated arc radiotherapy (VMAT) plan creation. The purpose of this study is to evaluate the quality of aTPS plans in the pelvic region. Material and Methods: Sixty patients with anal (n = 20), rectal (n = 20) or prostate (n = 20) cancer were retrospectively re-planned with the aTPS. Three IMRT (7-, 9- and 12-field) and two VMAT (2 and 3 arc) automatically generated plans (APs) were created per patient. The duration of the automated plan generation was registered. The best IMRT-AP and VMAT-AP for each patient were selected based on target coverage and dose to organs at risk (OARs). The AP quality was analyzed and compared to corresponding clinically accepted and manually generated VMAT plans (MPs) using several clinically relevant dose metrics. Calculation-based pre-treatment plan quality assurance (QA) was performed for all plans. Results: The median total duration to generate the five APs with the aTPS was 55 min, 39 min and 35 min for anal, prostate and rectal plans, respectively. The target coverage and the OAR sparing were equivalent for IMRT-APs and VMAT-MPs, while VMAT-Aps. demonstrated lower target dose homogeneity and higher dose to some OARs. Both conformity and homogeneity index were equivalent (rectal) or better (anal and prostate) for IMRT-APs compared to VMAT-MPs. All plans passed the patient-specific QA tolerance limit. Conclusions: The aTPS generates plans comparable to MPs within a short time-frame which is highly relevant for oART treatments.

KW - Automated treatment planning

KW - Intelligent optimization engine

KW - Online adaptive radiotherapy

KW - Pelvic cancer

KW - Plan quality

KW - Template-based Ethos TPS

U2 - 10.1016/j.tipsro.2022.04.001

DO - 10.1016/j.tipsro.2022.04.001

M3 - Journal article

C2 - 35464888

AN - SCOPUS:85128325218

VL - 22

SP - 30

EP - 36

JO - Technical Innovations and Patient Support in Radiation Oncology

JF - Technical Innovations and Patient Support in Radiation Oncology

SN - 2405-6324

ER -

ID: 314163014