Estrogen receptor alpha and risk for cognitive impairment in postmenopausal women
Research output: Contribution to journal › Journal article › Research › peer-review
The estrogen receptor alpha (ESR1) gene has been implicated in the process of cognitive impairment in elderly women. In a paired case-control study, we tested whether two ESR1 gene polymorphisms (the XbaI and PvuII sites) are risk factors for cognitive impairment as measured by the six-item Orientation-Memory-Concentration test in postmenopausal Danish women. Hormone replacement therapy, age and executive cognitive ability were examined as covariates for ESR1 gene effects on cognitive impairment. The XbaI polymorphism showed a marginal effect on cognitive abilities (P=0.054) when adjusted for executive cognitive ability. Using a dominant genetic model for the X allele, we found an elevated risk (executive cognitive ability adjusted P=0.033) for cognitive impairment. Hormone replacement therapy also had a borderline effect on cognitive ability (P=0.049) and this effect was reflected in executive cognitive ability. These data support that the ESR1 gene variants affect cognitive functioning in postmenopausal women.
Original language | English |
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Journal | Psychiatric Genetics |
Volume | 16 |
Issue number | 2 |
Pages (from-to) | 85-8 |
Number of pages | 4 |
ISSN | 0955-8829 |
DOIs | |
Publication status | Published - 2006 |
ID: 48611084