Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients

Research output: Contribution to journal › Journal article › Research › peer-review

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Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients. / Sondergaard, S R; Ullum, H; Skinhoj, P; Pedersen, Bente Klarlund.

In: Cellular Immunology, Vol. 197, No. 2, 01.11.1999, p. 91-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sondergaard, SR, Ullum, H, Skinhoj, P & Pedersen, BK 1999, 'Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients', Cellular Immunology, vol. 197, no. 2, pp. 91-8. https://doi.org/10.1006/cimm.1999.1565

APA

Sondergaard, S. R., Ullum, H., Skinhoj, P., & Pedersen, B. K. (1999). Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients. Cellular Immunology, 197(2), 91-8. https://doi.org/10.1006/cimm.1999.1565

Vancouver

Sondergaard SR, Ullum H, Skinhoj P, Pedersen BK. Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients. Cellular Immunology. 1999 Nov 1;197(2):91-8. https://doi.org/10.1006/cimm.1999.1565

Author

Sondergaard, S R ; Ullum, H ; Skinhoj, P ; Pedersen, Bente Klarlund. / Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients. In: Cellular Immunology. 1999 ; Vol. 197, No. 2. pp. 91-8.

Bibtex

@article{1fb7ff589d494028848a9eb3850d6712,

title = "Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients",

abstract = "HIV infection is known to cause changes in phenotype and function of natural killer (NK) cells. The aim of this study was to characterize the NK cells mobilized from peripheral reservoirs in human immunodeficiency virus (HIV)-infected patients and controls. Seventeen HIV-infected patients and eight age- and sex-matched controls received a 1-h epinephrine infusion. Epinephrine induced mobilization of high numbers of NK-like T cells with no difference between HIV-infected patients and controls. Interestingly, all subjects mobilized NK cells containing increased proportions of perforin, in particular the CD3(-)CD16(+)CD56(+) NK cell subset. The HIV-infected patients mobilized CD3(-)CD16(-)CD56(+) and CD3(-)CD16(+)CD56(+) NK cells to a lesser extent than did controls. In contrast, the HIV-infected patients mobilized relatively more CD3(-)CD16(+)CD56(-) NK cells independent of antiretroviral treatment. It is suggested that these cells represent an immature NK cell subpopulation possibly resulting from an impaired cytokine tissue environment in HIV-infected patients.",

keywords = "Adult, Blood Pressure, Catecholamines, Cell Movement, Cytotoxicity, Immunologic, Epinephrine, Female, HIV Infections, Heart Rate, Humans, Immunophenotyping, Killer Cells, Natural, Leukocyte Count, Male, Membrane Glycoproteins, Middle Aged, Perforin, Pore Forming Cytotoxic Proteins, T-Lymphocytes, Journal Article, Research Support, Non-U.S. Gov't",

author = "Sondergaard, {S R} and H Ullum and P Skinhoj and Pedersen, {Bente Klarlund}",

year = "1999",

month = nov,

day = "1",

doi = "10.1006/cimm.1999.1565",

language = "English",

volume = "197",

pages = "91--8",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press",

number = "2",

}

RIS

TY - JOUR

T1 - Epinephrine-induced mobilization of natural killer (NK) cells and NK-like T cells in HIV-infected patients

AU - Sondergaard, S R

AU - Ullum, H

AU - Skinhoj, P

AU - Pedersen, Bente Klarlund

PY - 1999/11/1

Y1 - 1999/11/1

N2 - HIV infection is known to cause changes in phenotype and function of natural killer (NK) cells. The aim of this study was to characterize the NK cells mobilized from peripheral reservoirs in human immunodeficiency virus (HIV)-infected patients and controls. Seventeen HIV-infected patients and eight age- and sex-matched controls received a 1-h epinephrine infusion. Epinephrine induced mobilization of high numbers of NK-like T cells with no difference between HIV-infected patients and controls. Interestingly, all subjects mobilized NK cells containing increased proportions of perforin, in particular the CD3(-)CD16(+)CD56(+) NK cell subset. The HIV-infected patients mobilized CD3(-)CD16(-)CD56(+) and CD3(-)CD16(+)CD56(+) NK cells to a lesser extent than did controls. In contrast, the HIV-infected patients mobilized relatively more CD3(-)CD16(+)CD56(-) NK cells independent of antiretroviral treatment. It is suggested that these cells represent an immature NK cell subpopulation possibly resulting from an impaired cytokine tissue environment in HIV-infected patients.

AB - HIV infection is known to cause changes in phenotype and function of natural killer (NK) cells. The aim of this study was to characterize the NK cells mobilized from peripheral reservoirs in human immunodeficiency virus (HIV)-infected patients and controls. Seventeen HIV-infected patients and eight age- and sex-matched controls received a 1-h epinephrine infusion. Epinephrine induced mobilization of high numbers of NK-like T cells with no difference between HIV-infected patients and controls. Interestingly, all subjects mobilized NK cells containing increased proportions of perforin, in particular the CD3(-)CD16(+)CD56(+) NK cell subset. The HIV-infected patients mobilized CD3(-)CD16(-)CD56(+) and CD3(-)CD16(+)CD56(+) NK cells to a lesser extent than did controls. In contrast, the HIV-infected patients mobilized relatively more CD3(-)CD16(+)CD56(-) NK cells independent of antiretroviral treatment. It is suggested that these cells represent an immature NK cell subpopulation possibly resulting from an impaired cytokine tissue environment in HIV-infected patients.

KW - Adult

KW - Blood Pressure

KW - Catecholamines

KW - Cell Movement

KW - Cytotoxicity, Immunologic

KW - Epinephrine

KW - Female

KW - HIV Infections

KW - Heart Rate

KW - Humans

KW - Immunophenotyping

KW - Killer Cells, Natural

KW - Leukocyte Count

KW - Male

KW - Membrane Glycoproteins

KW - Middle Aged

KW - Perforin

KW - Pore Forming Cytotoxic Proteins

KW - T-Lymphocytes

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1006/cimm.1999.1565

DO - 10.1006/cimm.1999.1565

M3 - Journal article

C2 - 10607426

VL - 197

SP - 91

EP - 98

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 2

ER -

ID: 180572027