Enterococcus phage Nonaheksakonda infecting clinical isolates of Enterococcus faecalis represents a new lineage in the family Siphoviridae
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Enterococcus phage Nonaheksakonda infecting clinical isolates of Enterococcus faecalis represents a new lineage in the family Siphoviridae. / Olsen, Nikoline S.; Nielsen, Katrine Johansen; Plöger, Maja; Kot, Witold; Hansen, Lars Hestbjerg.
In: Archives of Virology, Vol. 166, 2021, p. 593-599.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Enterococcus phage Nonaheksakonda infecting clinical isolates of Enterococcus faecalis represents a new lineage in the family Siphoviridae
AU - Olsen, Nikoline S.
AU - Nielsen, Katrine Johansen
AU - Plöger, Maja
AU - Kot, Witold
AU - Hansen, Lars Hestbjerg
PY - 2021
Y1 - 2021
N2 - Enterococcus phage Nonaheksakonda was isolated from wastewater, using a vancomycin-resistant strain of the opportunistic pathogen Enterococcus faecalis (VRE) as a host. Nonaheksakonda is a lytic phage infecting E. faecalis V583 and clinical isolates with at least four different multi-locus sequence types (MLSTs). The genome is a 41.9-kb double-stranded DNA molecule (34.6% GC) with 74 coding sequences. Comparative analysis revealed only one close relative, Enterococcus phage heks. All other phages had low protein similarity and shared less than 54% nucleotide sequence identity with phage Nonaheksakonda. The most similar phages were all classified and unclassified efquatroviruses. We propose that the phages Nonaheksakonda and heks represent a novel genus within the family Siphoviridae, order Caudovirales, for which we propose the name "Nonaheksakondavirus".
AB - Enterococcus phage Nonaheksakonda was isolated from wastewater, using a vancomycin-resistant strain of the opportunistic pathogen Enterococcus faecalis (VRE) as a host. Nonaheksakonda is a lytic phage infecting E. faecalis V583 and clinical isolates with at least four different multi-locus sequence types (MLSTs). The genome is a 41.9-kb double-stranded DNA molecule (34.6% GC) with 74 coding sequences. Comparative analysis revealed only one close relative, Enterococcus phage heks. All other phages had low protein similarity and shared less than 54% nucleotide sequence identity with phage Nonaheksakonda. The most similar phages were all classified and unclassified efquatroviruses. We propose that the phages Nonaheksakonda and heks represent a novel genus within the family Siphoviridae, order Caudovirales, for which we propose the name "Nonaheksakondavirus".
KW - COMPLETE GENOME SEQUENCE
KW - BACTERIOPHAGE
KW - RESISTANCE
KW - PREDICTION
KW - COMMENSALS
KW - VIRULENCE
KW - GENES
U2 - 10.1007/s00705-020-04905-y
DO - 10.1007/s00705-020-04905-y
M3 - Journal article
C2 - 33392817
VL - 166
SP - 593
EP - 599
JO - Archiv fur die gesamte Virusforschung
JF - Archiv fur die gesamte Virusforschung
SN - 0304-8608
ER -
ID: 255692425