Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging
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Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging. / Song, Jiangbo; Xiao, Li; Zhang, Zhehao; Wang, Yujin; Kouis, Panayiotis; Rasmussen, Lene Juel; Dai, Fangyin.
In: Frontiers in Cell and Developmental Biology, Vol. 12, 1347286, 2024.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging
AU - Song, Jiangbo
AU - Xiao, Li
AU - Zhang, Zhehao
AU - Wang, Yujin
AU - Kouis, Panayiotis
AU - Rasmussen, Lene Juel
AU - Dai, Fangyin
N1 - Publisher Copyright: Copyright © 2024 Song, Xiao, Zhang, Wang, Kouis, Rasmussen and Dai.
PY - 2024
Y1 - 2024
N2 - Mitochondria, the versatile organelles crucial for cellular and organismal viability, play a pivotal role in meeting the energy requirements of cells through the respiratory chain located in the inner mitochondrial membrane, concomitant with the generation of reactive oxygen species (ROS). A wealth of evidence derived from contemporary investigations on reproductive longevity strongly indicates that the aberrant elevation of ROS level constitutes a fundamental factor in hastening the aging process of reproductive systems which are responsible for transmission of DNA to future generations. Constant changes in redox status, with a pro-oxidant shift mainly through the mitochondrial generation of ROS, are linked to the modulation of physiological and pathological pathways in gametes and reproductive tissues. Furthermore, the quantity and quality of mitochondria essential to capacitation and fertilization are increasingly associated with reproductive aging. The article aims to provide current understanding of the contributions of ROS derived from mitochondrial respiration to the process of reproductive aging. Moreover, understanding the impact of mitochondrial dysfunction on both female and male fertility is conducive to finding therapeutic strategies to slow, prevent or reverse the process of gamete aging, and thereby increase reproductive longevity.
AB - Mitochondria, the versatile organelles crucial for cellular and organismal viability, play a pivotal role in meeting the energy requirements of cells through the respiratory chain located in the inner mitochondrial membrane, concomitant with the generation of reactive oxygen species (ROS). A wealth of evidence derived from contemporary investigations on reproductive longevity strongly indicates that the aberrant elevation of ROS level constitutes a fundamental factor in hastening the aging process of reproductive systems which are responsible for transmission of DNA to future generations. Constant changes in redox status, with a pro-oxidant shift mainly through the mitochondrial generation of ROS, are linked to the modulation of physiological and pathological pathways in gametes and reproductive tissues. Furthermore, the quantity and quality of mitochondria essential to capacitation and fertilization are increasingly associated with reproductive aging. The article aims to provide current understanding of the contributions of ROS derived from mitochondrial respiration to the process of reproductive aging. Moreover, understanding the impact of mitochondrial dysfunction on both female and male fertility is conducive to finding therapeutic strategies to slow, prevent or reverse the process of gamete aging, and thereby increase reproductive longevity.
KW - aging
KW - fertility
KW - gamete quality
KW - mitochondria
KW - reproductive health
KW - ROS
U2 - 10.3389/fcell.2024.1347286
DO - 10.3389/fcell.2024.1347286
M3 - Review
C2 - 38465288
AN - SCOPUS:85186911897
VL - 12
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
SN - 2296-634X
M1 - 1347286
ER -
ID: 385230285