Effect of serotonin receptor blockade on endocrine and cardiovascular responses to head-up tilt in humans
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Effect of serotonin receptor blockade on endocrine and cardiovascular responses to head-up tilt in humans. / Matzen, S; Secher, N H; Knigge, U; Pawelczyk, J; Perko, G; Iversen, H; Bach, F W; Warberg, J; Iversen, Helle Klingenberg.
In: Acta Physiologica Scandinavica, Vol. 149, No. 2, 10.1993, p. 163-76.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Effect of serotonin receptor blockade on endocrine and cardiovascular responses to head-up tilt in humans
AU - Matzen, S
AU - Secher, N H
AU - Knigge, U
AU - Pawelczyk, J
AU - Perko, G
AU - Iversen, H
AU - Bach, F W
AU - Warberg, J
AU - Iversen, Helle Klingenberg
PY - 1993/10
Y1 - 1993/10
N2 - Effects of blockade of serotonin (5-HT) receptors on the integrated cardiovascular and endocrine adaptations during head-up tilt were investigated in normal men. In control experiments 50 degrees head-up tilt increased heart rate (HR), total peripheral resistance (TPR), plasma renin activity (PRA) and sympathetic activity (plasma noradrenaline; NA). A moderate increase in pituitary-adrenal hormones (plasma ACTH, beta-END and cortisol) was observed. After a mean tilt time of 30 +/- 5 min (n = 20) presyncopal symptoms associated with decreases in HR, TPR and arterial pressure occurred. At this time pituitary hormones, cortisol, adrenomedullary (plasma adrenaline; A) as well as vagal activity (plasma pancreatic polypeptide) were markedly increased, whereas sympathetic activity (plasma NA) decreased. The 5-HT1+2 receptor antagonist methysergide did not significantly interfere with cardiovascular variables but attenuated the response of NA, prolactin (PRL), beta-endorphin (beta-END) and PRA (P < 0.02). The 5-HT2-receptor antagonist ketanserin reduced the tolerated tilt time (10 +/- 4 vs. 32 +/- 2 min; P < 0.0003, n = 7) but had no significant effects on hormonal variables. The 5-HT3-receptor antagonist ondansetron abolished the adrenomedullary response to hypotension without affecting cardiovascular tolerance or the activity of the pituitary-adrenal axis. The results suggest that serotonergic mechanisms may be involved in the integrated cardiovascular and endocrine responses to central blood volume depletion in humans.
AB - Effects of blockade of serotonin (5-HT) receptors on the integrated cardiovascular and endocrine adaptations during head-up tilt were investigated in normal men. In control experiments 50 degrees head-up tilt increased heart rate (HR), total peripheral resistance (TPR), plasma renin activity (PRA) and sympathetic activity (plasma noradrenaline; NA). A moderate increase in pituitary-adrenal hormones (plasma ACTH, beta-END and cortisol) was observed. After a mean tilt time of 30 +/- 5 min (n = 20) presyncopal symptoms associated with decreases in HR, TPR and arterial pressure occurred. At this time pituitary hormones, cortisol, adrenomedullary (plasma adrenaline; A) as well as vagal activity (plasma pancreatic polypeptide) were markedly increased, whereas sympathetic activity (plasma NA) decreased. The 5-HT1+2 receptor antagonist methysergide did not significantly interfere with cardiovascular variables but attenuated the response of NA, prolactin (PRL), beta-endorphin (beta-END) and PRA (P < 0.02). The 5-HT2-receptor antagonist ketanserin reduced the tolerated tilt time (10 +/- 4 vs. 32 +/- 2 min; P < 0.0003, n = 7) but had no significant effects on hormonal variables. The 5-HT3-receptor antagonist ondansetron abolished the adrenomedullary response to hypotension without affecting cardiovascular tolerance or the activity of the pituitary-adrenal axis. The results suggest that serotonergic mechanisms may be involved in the integrated cardiovascular and endocrine responses to central blood volume depletion in humans.
KW - Adrenocorticotropic Hormone
KW - Blood Pressure
KW - Heart Rate
KW - Hemodynamics
KW - Hormones
KW - Humans
KW - Hydrocortisone
KW - Ketanserin
KW - Male
KW - Methysergide
KW - Norepinephrine
KW - Ondansetron
KW - Posture
KW - Prolactin
KW - Reference Values
KW - Renin
KW - Serotonin Antagonists
KW - Vagus Nerve
KW - Vascular Resistance
KW - beta-Endorphin
U2 - 10.1111/j.1748-1716.1993.tb09609.x
DO - 10.1111/j.1748-1716.1993.tb09609.x
M3 - Journal article
C2 - 8266806
VL - 149
SP - 163
EP - 176
JO - Acta Physiologica Scandinavica
JF - Acta Physiologica Scandinavica
SN - 0001-6772
IS - 2
ER -
ID: 128985515