Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial
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- Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring
Final published version, 1.31 MB, PDF document
Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies. Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden. Effects of praziquantel treatment during pregnancy on responses among offspring are unknown.
| Original language | English |
|---|---|
| Journal | B M C Infectious Diseases |
| Volume | 11 |
| Issue number | 234 |
| Number of pages | 13 |
| ISSN | 1471-2334 |
| DOIs | |
| Publication status | Published - 2011 |
- Animals, Antibodies, Protozoan, Antigens, Protozoan, Antiprotozoal Agents, Cytokines, Female, Humans, Immunity, Maternally-Acquired, Infant, Infant, Newborn, Leukocytes, Mononuclear, Placebos, Praziquantel, Pregnancy, Pregnancy Complications, Parasitic, Schistosoma mansoni, Schistosomiasis mansoni, Treatment Outcome, Uganda
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