Effect of moderate beer consumption (with and without ethanol) on cardiovascular health in postmenopausal women
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BACKGROUND: The main aim of this 2-year non-randomized parallel controlled clinical pilot trial was to evaluate the long-term effect of a moderate daily intake of beer (with and without alcohol) on cardiovascular health in postmenopausal women. A total of 34 participants were grouped into three study arms: 16 were administered alcoholic beer, 6 consumed non-alcoholic beer, and 12 were in the control group. Changes in glucose metabolism, lipid profile, liver enzymes, anthropometric measurements, body composition, and blood pressure variables were monitored. Data on medical history, diet, and exercise were collected, and gustatory capacities were determined. RESULTS: Moderate consumption of beer, both alcoholic and non-alcoholic, seemed to have positive effects on biochemical indicators of cardiovascular health in postmenopausal women, with 660 mL day−1 of non-alcoholic beer reducing low-density lipoprotein cholesterol blood levels, and 330 mL day−1 of alcoholic beer increasing high-density lipoprotein cholesterol. The evolution of changes in android and gynoid fat percentage and their ratio differed significantly between study groups, which was attributable to either the interventions or the disparity between groups regarding the time elapsed since menopause onset. Iso-α-acids recognition threshold could be involved in intervention group election, whereas the sensory phenotypes studied were not associated with alcohol drinking frequency. CONCLUSIONS: Moderate beer consumption was found to improve the lipid profile of postmenopausal women, although their effects in preventing cardiometabolic alterations deserve further research (trial registration number: ISRCTN13825020; https://doi.org/10.1186/ISRCTN13825020).
| Original language | English |
|---|---|
| Journal | Journal of the Science of Food and Agriculture |
| Volume | 103 |
| Issue number | 15 |
| Pages (from-to) | 7506-7516 |
| Number of pages | 11 |
| ISSN | 0022-5142 |
| DOIs | |
| Publication status | Published - 2023 |
| Externally published | Yes |
Bibliographical note
Funding Information:
RL and AT have received funding from The European Foundation for Alcohol Research (ERAB). RL has received lecture fees and travel support from Cerveceros de España and Wine in Moderation. RE reports grants from Fundación Dieta Mediterránea (Spain) and Cerveza y Salud (Spain). He also reports personal fees for giving lectures from Brewers of Europe (Belgium), Fundación Cerveza y Salud (Spain), Lilly Laboratories (Spain), and Wine and Culinary International Forum (Spain); non‐financial support to organize a National Congress on Nutrition; and feeding trials with product from Grand Fountain and Uriach Laboratories (Spain). No other conflicts of interest related to the current paper were reported.
Funding Information:
This research has been supported by the European Foundation for Alcohol Research (ERAB) (EA 1514, EA 1515, and EA 1517) PID2020-114022RB-I00 and CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades (AEI/FEDER, UE), Generalitat de Catalunya (GC) (2021-SGR-00334). INSA-UB is a Mara de Maeztu Unit of Excellence (grant CEX2021-001234-M funded by MICIN/AEI/FEDER, UE). None of the funders had a role in the study design, implementation, analysis or interpretation of the data, or the writing of the manuscript. MT is grateful for the APIF 2018–2019 fellowship from the University of Barcelona. AT is a Serra-Hunter fellow. We thank all the volunteers for their participation and contribution to the trial. We wish to thank the CCiT-UB for the use of the mass spectrometry equipment.
Funding Information:
This research has been supported by the European Foundation for Alcohol Research (ERAB) (EA 1514, EA 1515, and EA 1517) PID2020‐114022RB‐I00 and CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades (AEI/FEDER, UE), Generalitat de Catalunya (GC) (2021‐SGR‐00334). INSA‐UB is a Mara de Maeztu Unit of Excellence (grant CEX2021‐001234‐M funded by MICIN/AEI/FEDER, UE). None of the funders had a role in the study design, implementation, analysis or interpretation of the data, or the writing of the manuscript. MT is grateful for the APIF 2018–2019 fellowship from the University of Barcelona. AT is a Serra‐Hunter fellow.
Publisher Copyright:
© 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
- alcohol drinking, bitter taste, lipid profile, phytoestrogens, polyphenols, PTC phenotype
Research areas
ID: 403454359